Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Multifunctional Hybrid Material for Endoprosthetic Implants Based on Alumina-Toughened Zirconia Ceramics and Additively Manufactured TiNbTa Alloy

Jan-Oliver Sass
* ,
Paul Henke
ORCID logo ,
Aurica Mitrovic
,
Markus Weinmann
ORCID logo ,
Daniel Kluess
ORCID logo ,
Jan Johannsen
ORCID logo ,
Marie-Luise Sellin
,
Ulrich Lembke
,
Daniel Reimer
,
Cornelia Lork
,
Anika Jonitz-Heincke
,
Rainer Bader
Version 1 : Received: 14 March 2024 / Approved: 17 March 2024 / Online: 18 March 2024 (07:23:55 CET)

A peer-reviewed article of this Preprint also exists.

Sass, J.-O.; Henke, P.; Mitrovic, A.; Weinmann, M.; Kluess, D.; Johannsen, J.; Sellin, M.-L.; Lembke, U.; Reimer, D.; Lork, C.; Jonitz-Heincke, A.; Bader, R. Multifunctional Hybrid Material for Endoprosthetic Implants Based on Alumina-Toughened Zirconia Ceramics and Additively Manufactured TiNbTa Alloys. Materials 2024, 17, 1838. Sass, J.-O.; Henke, P.; Mitrovic, A.; Weinmann, M.; Kluess, D.; Johannsen, J.; Sellin, M.-L.; Lembke, U.; Reimer, D.; Lork, C.; Jonitz-Heincke, A.; Bader, R. Multifunctional Hybrid Material for Endoprosthetic Implants Based on Alumina-Toughened Zirconia Ceramics and Additively Manufactured TiNbTa Alloys. Materials 2024, 17, 1838.

Abstract

Aseptic implant loosening after total joint replacement is partially influenced by material-specific factors when cobalt-chromium alloys are used, including osteolysis induced by wear- and corrosion products, and stress shielding. Here, we aim to characterize a hybrid material consisting of alumina-toughened zirconia ceramics (ATZ) and additively manufactured Ti-35Nb-6Ta (TiNbTa), joined by a glass solder. The structure of the joint, static and fatigue shear strength, the influence of accelerated aging, and the cytotoxicity using an elution assay with human osteoblasts is characterized. Furthermore, the biomechanical properties of functional demonstrators of a femoral component for total knee replacements are evaluated. TiNbTa-ATZ specimens showed a homogenous joint with statistical distributed micro-pores and a slight accumulation of Al-rich compounds at the glass solder-TiNbTa interface. The static shear strength was 26.4 ± 4.2 MPa (Ti-ATZ reference: 38.2 ± 14.4 MPa, p = 0.117), all specimens survived 107 cycles of shear loading to 10 MPa, and aging did not reduce the strength. TiNbTa-ATZ did not impair the proliferation and metabolic activity of human osteoblasts. Functional demonstrators of TiNbTa-ATZ provided a maximum bearable extension-flexion moment of 40.7 ± 2.2 Nm. Biomechanical and biological properties of TiNbTa-ATZ demonstrate potential application for endoprosthetic implants.

Keywords

implant material; hybrid; alumina-toughened zirconia; beta titanium; glass soldering; additive manufacturing; total knee replacement; aseptic loosening

Subject

Chemistry and Materials Science, Biomaterials

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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