Version 1
: Received: 14 March 2024 / Approved: 15 March 2024 / Online: 15 March 2024 (07:50:02 CET)
Version 2
: Received: 15 March 2024 / Approved: 18 March 2024 / Online: 18 March 2024 (09:32:30 CET)
Al-Khazaleh, A.K.; Chang, D.; Münch, G.W.; Bhuyan, D.J. The Gut Connection: Exploring the Possibility of Implementing Gut Microbial Metabolites in Lymphoma Treatment. Cancers2024, 16, 1464.
Al-Khazaleh, A.K.; Chang, D.; Münch, G.W.; Bhuyan, D.J. The Gut Connection: Exploring the Possibility of Implementing Gut Microbial Metabolites in Lymphoma Treatment. Cancers 2024, 16, 1464.
Al-Khazaleh, A.K.; Chang, D.; Münch, G.W.; Bhuyan, D.J. The Gut Connection: Exploring the Possibility of Implementing Gut Microbial Metabolites in Lymphoma Treatment. Cancers2024, 16, 1464.
Al-Khazaleh, A.K.; Chang, D.; Münch, G.W.; Bhuyan, D.J. The Gut Connection: Exploring the Possibility of Implementing Gut Microbial Metabolites in Lymphoma Treatment. Cancers 2024, 16, 1464.
Abstract
Recent research has implicated the gut microbiota in the development of lymphoma. Dysbiosis of the gut microbial community can disrupt the production of gut microbial metabolites, thereby impacting host physiology and potentially contributing to lymphoma. Dysbiosis-driven release of gut microbial metabolites such as lipopolysaccharides can promote chronic inflammation, potentially elevating the risk of lymphoma. In contrast, gut microbial metabolites, such as short-chain fatty acids, have shown promise in preclinical studies by promoting regulatory T-cell function, suppressing inflammation, and preventing lymphoma. Another metabolite, urolithin A, exhibited immunomodulatory and antiproliferative properties against lymphoma cell lines in vitro. While research on the role of gut microbial metabolites in lymphoma is limited, this article emphasizes the need to comprehend their significance, including therapeutic applications, molecular mechanisms of action, and interactions with standard chemotherapies. The article also suggests promising directions for future research in this emerging lymphoma and gut microbiome investigation field.
Keywords
Lymphoma; Hodgkin’s lymphoma; Non-Hodgkin’s lymphoma; Burkitt lymphoma; gut microbiota; short-chain fatty acids; gut metabolites; postbiotics
Subject
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
