Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Inflammation Indexes PLR, SII, AISI, MLR, NLPR and MCVL in Peripartum Treated Thrombophilia Patients Undergoing Cesarean Section at Term-STROBE Compliant

Catalina Filip
ORCID logo ,
Roxana Covali
* ORCID logo ,
Demetra Socolov
,
Ingrid Andrada Vasilache
ORCID logo ,
Alexandru Carauleanu
,
Mona Akad
* ,
Ioana Sadyie Scripcariu
,
Tudor Butureanu
ORCID logo ,
Gabriela Dumachita-Sargu
,
Lucian Vasile Boiculese
,
Alina Melinte
,
Razvan Socolov
ORCID logo
Version 1 : Received: 13 March 2024 / Approved: 14 March 2024 / Online: 14 March 2024 (11:12:44 CET)

How to cite: Filip, C.; Covali, R.; Socolov, D.; Vasilache, I.A.; Carauleanu, A.; Akad, M.; Scripcariu, I.S.; Butureanu, T.; Dumachita-Sargu, G.; Boiculese, L.V.; Melinte, A.; Socolov, R. Inflammation Indexes PLR, SII, AISI, MLR, NLPR and MCVL in Peripartum Treated Thrombophilia Patients Undergoing Cesarean Section at Term-STROBE Compliant. Preprints 2024, 2024030814. https://doi.org/10.20944/preprints202403.0814.v1 Filip, C.; Covali, R.; Socolov, D.; Vasilache, I.A.; Carauleanu, A.; Akad, M.; Scripcariu, I.S.; Butureanu, T.; Dumachita-Sargu, G.; Boiculese, L.V.; Melinte, A.; Socolov, R. Inflammation Indexes PLR, SII, AISI, MLR, NLPR and MCVL in Peripartum Treated Thrombophilia Patients Undergoing Cesarean Section at Term-STROBE Compliant. Preprints 2024, 2024030814. https://doi.org/10.20944/preprints202403.0814.v1

Abstract

(1) Background: Thrombophilia is a tendency towards hypercoagulability, and it is increased by pregnancy, peaking around delivery. Research question: does thrombophilia stimulate the in-flammatory state of the patient, already suppressed by pregnancy? (2) Methods: Eighty thrombo-philia patients admitted for delivery between 1/10/2017 and 1/12/2021 were prospectively stud-ied, together with eighty age- and para-matched control patients. Patients were admitted for de-livery at term by means of cesarean section. The inflammation indexes from the complete blood count values analysis during both the 24 hours before and after labor—extracted from the hospi-tal’s medical records—were calculated and then correlated with uterine involution. (3) Results: Except for the PLR, most of the numerous inflammation indexes studied were not significantly different in treated thrombophilia patients, before and after delivery, compared to non-thrombophilia patients. Only when we split the patients, based on the uterine haematometra in the first 24-48 hours postpartum, we found out that the few treated thrombophilia patients with haematometra (14 with haematometra out of 79 with treated thrombophilia) had elevated SII and AISI antepartum. In pregnant patients treated for thrombophilia, MLR is higher in pa-tients without the Rh factor than in those with the Rh factor. In non-thrombophilia patients, MCVL and NLPR increased with age and before labor, while SII and AISI increased with age postpartum. (4) Conclusions: Thrombophilia did not stimulate the inflammatory state of the pa-tient, already suppressed by pregnancy.

Keywords

thrombophilia; pregnancy; postpartum uterine ultrasonographic scale; SII; AISI; MLR; PLR; MCVL; NLPR; Rh factor

Subject

Medicine and Pharmacology, Obstetrics and Gynaecology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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