Version 1
: Received: 8 March 2024 / Approved: 12 March 2024 / Online: 12 March 2024 (08:13:16 CET)
How to cite:
Allemann, A.; Staubli, S.M.; Nebiker, C.A. Trypsin and Trypsinogen Activation Peptide in the Prediction of Severity of Acute Pancreatitis. Preprints2024, 2024030681. https://doi.org/10.20944/preprints202403.0681.v1
Allemann, A.; Staubli, S.M.; Nebiker, C.A. Trypsin and Trypsinogen Activation Peptide in the Prediction of Severity of Acute Pancreatitis. Preprints 2024, 2024030681. https://doi.org/10.20944/preprints202403.0681.v1
Allemann, A.; Staubli, S.M.; Nebiker, C.A. Trypsin and Trypsinogen Activation Peptide in the Prediction of Severity of Acute Pancreatitis. Preprints2024, 2024030681. https://doi.org/10.20944/preprints202403.0681.v1
APA Style
Allemann, A., Staubli, S.M., & Nebiker, C.A. (2024). Trypsin and Trypsinogen Activation Peptide in the Prediction of Severity of Acute Pancreatitis. Preprints. https://doi.org/10.20944/preprints202403.0681.v1
Chicago/Turabian Style
Allemann, A., Sebastian Manuel Staubli and Christian Andreas Nebiker. 2024 "Trypsin and Trypsinogen Activation Peptide in the Prediction of Severity of Acute Pancreatitis" Preprints. https://doi.org/10.20944/preprints202403.0681.v1
Abstract
OBJECTIVES: To assess the predictive value of serum trypsin and Trypsinogen Activation Peptide (TAP) for the severity of AP by means of a single center cohort study as well as a systematic review of the current literature. METHODS: The literature search was conducted using Medline (PubMed), EMBASE and the Cochrane Central Register. A total of 142 patients with acute pancreatitis (AP) were included in the cohort study and parameters of the revised Atlanta criteria of 2012 and the APACHE II were assessed. RESULTS: The review showed promising results for the predictive value of serum trypsinogen-2, but conflicting results for serum TAP and trypsin. In the cohort study, patients were observed for 4 days after diagnosis of AP: 9 patients had severe AP, 35 patients had moderate AP and 81 patients had mild AP. The ratio of the geometric mean of severe vs mild AP for trypsin was 0.72 (95% CI: 0.51-1.00), p=0.053 and for TAP 0.74 (95% CI: 0.54-1.01), p=0.055 respectively. CONCLUSION: The cohort study showed an inverse correlation of serum levels of TAP and trypsin with severity of AP. Serum TAP and trypsin have an inferior predictive value of severity of AP compared to the clinical APACHE II score.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
