Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Developing Captive Marmosets as a Translational Geroscience Model to Study the Microbiome and Healthy Aging

Kelly R. Reveles
* ,
Alexana J. Hickmott
,
Kelsey A. Strey
,
Aaryn C. Mustoe
,
Juan Pablo Arroyo
,
Michael L. Power
ORCID logo ,
Benjamin J. Ridenhour
ORCID logo ,
Katherine R. Amato
,
Corinna N. Ross
ORCID logo
Version 1 : Received: 6 March 2024 / Approved: 7 March 2024 / Online: 8 March 2024 (01:55:32 CET)

A peer-reviewed article of this Preprint also exists.

Reveles, K.R.; Hickmott, A.J.; Strey, K.A.; Mustoe, A.C.; Arroyo, J.P.; Power, M.L.; Ridenhour, B.J.; Amato, K.R.; Ross, C.N. Developing the Common Marmoset as a Translational Geroscience Model to Study the Microbiome and Healthy Aging. Microorganisms 2024, 12, 852. Reveles, K.R.; Hickmott, A.J.; Strey, K.A.; Mustoe, A.C.; Arroyo, J.P.; Power, M.L.; Ridenhour, B.J.; Amato, K.R.; Ross, C.N. Developing the Common Marmoset as a Translational Geroscience Model to Study the Microbiome and Healthy Aging. Microorganisms 2024, 12, 852.

Abstract

Emerging data support associations between depletion of the healthy gut microbiome and aging-related physiological decline and disease. In humans, fecal microbiota transplantation (FMT) has been used successfully to restore gut microbiome structure and function to treat C. difficile infections, but application to healthy aging has been scarcely investigated. The marmoset is an excellent model for evaluating microbiome-mediated changes with age and interventional treatments due to their relatively shorter lifespan and many social, behavioral, and physiological functions that mimic human aging. This review 1) provides an overview of the rationale for FMT to support healthy aging using the marmoset as a translational geroscience model, 2) summarizes prior use of FMT in marmosets, 3) outlines a protocol for studying FMT in aging marmosets, and 4) describes knowledge gaps and future research needs in this field.

Keywords

common marmoset; aging; geroscience; microbiome; fecal microbiota transplantation

Subject

Biology and Life Sciences, Animal Science, Veterinary Science and Zoology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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