Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Laparoscopic Total Pelvic Exenteration Compared to the Open Approach in Advanced Pelvic Malignances

Lidia Rodriguez-Ortiz
,
Maria del Mar Lopez-Cuevas
,
Ana Vallejo-Lesmes
,
Gonzalo Gomez-Dueñas
,
Manuel Bergillos-Gimenez
,
Angela Casado-Adam
,
Juan Manuel Sanchez-Hidalgo
,
Antonio Gordon-Suarez
,
Blanca Rufián-Andujar
,
Francisca Valenzuela-Molina
,
Antonio Romero-Ruiz
,
Mari C. Vazquez-Borrego
* ,
Alvaro Arjona-Sanchez
* ORCID logo
Version 1 : Received: 5 March 2024 / Approved: 6 March 2024 / Online: 6 March 2024 (11:11:19 CET)

How to cite: Rodriguez-Ortiz, L.; Lopez-Cuevas, M.D.M.; Vallejo-Lesmes, A.; Gomez-Dueñas, G.; Bergillos-Gimenez, M.; Casado-Adam, A.; Sanchez-Hidalgo, J.M.; Gordon-Suarez, A.; Rufián-Andujar, B.; Valenzuela-Molina, F.; Romero-Ruiz, A.; Vazquez-Borrego, M.C.; Arjona-Sanchez, A. Laparoscopic Total Pelvic Exenteration Compared to the Open Approach in Advanced Pelvic Malignances. Preprints 2024, 2024030354. https://doi.org/10.20944/preprints202403.0354.v1 Rodriguez-Ortiz, L.; Lopez-Cuevas, M.D.M.; Vallejo-Lesmes, A.; Gomez-Dueñas, G.; Bergillos-Gimenez, M.; Casado-Adam, A.; Sanchez-Hidalgo, J.M.; Gordon-Suarez, A.; Rufián-Andujar, B.; Valenzuela-Molina, F.; Romero-Ruiz, A.; Vazquez-Borrego, M.C.; Arjona-Sanchez, A. Laparoscopic Total Pelvic Exenteration Compared to the Open Approach in Advanced Pelvic Malignances. Preprints 2024, 2024030354. https://doi.org/10.20944/preprints202403.0354.v1

Abstract

Introduction Total pelvic exenteration (TPE) is a highly complex surgery associated with a high morbidity rate of 40% in reference units. It is performed for advanced or recurrences tumors in the pelvis with infiltration of multiple organs. Sometimes TPE is indicated in situations of palliation due to the side effects of radiotherapy or tumor progression. The aim of our study is to evaluate a single center experience in TPEs using a minimally invasive approach (LTPE) and compare the perioperative outcomes with the open technique (OTPE). Material and methods A prospective study of the TPE carried out in our unit between 2013-2023 was used. All anterior and posterior exenterations were discarded. Perioperative outcomes were evaluated. Results A total of 19 TPEs were analyzed, 9 LTPEs and 10 OTPEs. Most tumors originated from the colon and cervix. Hyperthermic intraperitoneal chemotherapy (HIPEC) was applied in one case of LTPE and intraoperative radiotherapy (IORT) in one case of OTPE. Cases with palliative intent were one in each group. Surgery time was 407 minutes for LTPE and 367 min for OPTE (p=0.38). Length of hospital stay was longer in the OPTE group at 21.6 days vs LTPE with 10.1 days, (p=0.23). The R0 rate excluding palliative cases was 88.9% for LTPE vs. 70% for OPTE (p=0.33). Major morbidity (grade III) was 45% in the LTPE group with no mortality and 40% (grade III/IV) in the OPTE group with one patient dying on admission. Survival was similar in both groups. Conclusion LTPE is a feasible and safe approach with similar perioperative outcomes and a trend toward shorter hospital stay.

Keywords

pelvic exenteration; pelvic malignances; rectum; cervix; endometrial cancer

Subject

Medicine and Pharmacology, Surgery

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.