Version 1
: Received: 5 March 2024 / Approved: 5 March 2024 / Online: 6 March 2024 (13:17:11 CET)
How to cite:
Alekseenko, I.; Zhukova, L.; Kondratyeva, L.; Chernov, I.; Sverdlov, E. The Untouched Reserve of Cancer Chemotherapy: Tumor Cell Communication as a Promising Supramolecular Target. Preprints2024, 2024030352. https://doi.org/10.20944/preprints202403.0352.v1
Alekseenko, I.; Zhukova, L.; Kondratyeva, L.; Chernov, I.; Sverdlov, E. The Untouched Reserve of Cancer Chemotherapy: Tumor Cell Communication as a Promising Supramolecular Target. Preprints 2024, 2024030352. https://doi.org/10.20944/preprints202403.0352.v1
Alekseenko, I.; Zhukova, L.; Kondratyeva, L.; Chernov, I.; Sverdlov, E. The Untouched Reserve of Cancer Chemotherapy: Tumor Cell Communication as a Promising Supramolecular Target. Preprints2024, 2024030352. https://doi.org/10.20944/preprints202403.0352.v1
APA Style
Alekseenko, I., Zhukova, L., Kondratyeva, L., Chernov, I., & Sverdlov, E. (2024). The Untouched Reserve of Cancer Chemotherapy: Tumor Cell Communication as a Promising Supramolecular Target. Preprints. https://doi.org/10.20944/preprints202403.0352.v1
Chicago/Turabian Style
Alekseenko, I., Igor Chernov and Eugene Sverdlov. 2024 "The Untouched Reserve of Cancer Chemotherapy: Tumor Cell Communication as a Promising Supramolecular Target" Preprints. https://doi.org/10.20944/preprints202403.0352.v1
Abstract
52 years have passed since President Nixon launched the "War on Cancer". The goals outlined by the President were not achieved because cancer treatment applied such as chemotherapy, radiotherapy, and targeted therapy have not fully met expectations. We suggest a new chemotherapeutic strategy: disrupting the communication between cancer cells and their microenvironment by chemical means. Immunological synapses that form between cancer cells and immune or other stromal cells provide an attractive target for this approach. Synapses form ligand-receptor clusters within interface of the interacting cells. Despite their differences, synapses share common properties: intercellular protein clusters; the proximity of these proteins; and their cooperative interaction making a synapse an unified functional unit. Synapses provide the limited space for the focused intercellular exchange of signaling molecules and particles. Therefore, destruction of synapses is expected to cause collapse of various tumor types. Additionally, the clustered arrangement of synapse components offers opportunities to increase treatment safety by reducing the concentration of cell impermeable agents used, to enhance its specificity applying cross-linking reagents, thus restricting modifications of surface-exposed molecules. By attaching a cleavable cell permeable toxic agent to a crosslinker should further enhance a killing potential in treating cancer. The proposed approach promises to be simple, universal, and less expensive than existing cancer therapy methods.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
