Neri, L.; Marziani, B.; Sebastiani, P.; Del Beato, T.; Colanardi, A.; Legge, M.P.; Aureli, A. Aggressiveness in Italian Children with ADHD: MAOA Gene Polymorphism Involvement. Diseases2024, 12, 70.
Neri, L.; Marziani, B.; Sebastiani, P.; Del Beato, T.; Colanardi, A.; Legge, M.P.; Aureli, A. Aggressiveness in Italian Children with ADHD: MAOA Gene Polymorphism Involvement. Diseases 2024, 12, 70.
Neri, L.; Marziani, B.; Sebastiani, P.; Del Beato, T.; Colanardi, A.; Legge, M.P.; Aureli, A. Aggressiveness in Italian Children with ADHD: MAOA Gene Polymorphism Involvement. Diseases2024, 12, 70.
Neri, L.; Marziani, B.; Sebastiani, P.; Del Beato, T.; Colanardi, A.; Legge, M.P.; Aureli, A. Aggressiveness in Italian Children with ADHD: MAOA Gene Polymorphism Involvement. Diseases 2024, 12, 70.
Abstract
ADHD is a neurodevelopmental disorder that children and also adults can develop. A complex interplay of genetic and environmental factors may underlie interindividual variability in ADHD and potentially related aggressive behavior. Using high-resolution molecular biology techniques, we investigated the impact of some MAOA and SLC6A4 variations on ADHD and aggressive behavior in a group of 80 Italian children with ADHD and in 80 healthy controls.We found that homozygous genotypes of MAOA rs6323 and rs1137070 were associated with an increased risk of ADHD (p=0.02 and p=0.03, respectively), instead the heterozygous genotypes (GT of rs6323 and CT of rs1137030) (p=0.0002 and p=0.0006) were strongly linked to a lower risk of developing this disorder. In patients with aggressive behavior, we highligted only a weak negative association of both MAOA polymorphisms (heterozygous genotypes) with aggressiveness then, suggesting that these genotypes maybe protective towards specific changes in behavior (p=0.05). Interestingly, an increase of the GG genotype of rs6323 (p=0.01) and a decrease of GT genotype (p=0.0005) was also found in patients without aggressive behavior compared with controls. Regarding 5HTT gene genotyping, no allele and genotype differences have been detected among patients and controls. Our work shows that defining a genetic profile of ADHD may help to early detect those patients who are more vulnerable to ADHD and/or antisocial and aggressive behavior and to design precision-targeted therapies.
Keywords
ADHD; Aggressive behavior; MAOA; 5-HTT.
Subject
Medicine and Pharmacology, Psychiatry and Mental Health
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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