Version 1
: Received: 29 February 2024 / Approved: 1 March 2024 / Online: 4 March 2024 (06:04:20 CET)
How to cite:
Gusson-Zanetoni, J.P.; Cardoso, L.P.; De Sousa, S.O.; Silva, L.L.D.M.M.; Martinho, J.D.O.; Henrique, T.; Tajara, E.H.; Oliani, S.M.; Rodrigues-Lisoni, F.C. Molecular Aspects of Piperine in Signaling Pathways Associated with Inflammation in Head and Neck Cancer. Preprints2024, 2024030034. https://doi.org/10.20944/preprints202403.0034.v1
Gusson-Zanetoni, J.P.; Cardoso, L.P.; De Sousa, S.O.; Silva, L.L.D.M.M.; Martinho, J.D.O.; Henrique, T.; Tajara, E.H.; Oliani, S.M.; Rodrigues-Lisoni, F.C. Molecular Aspects of Piperine in Signaling Pathways Associated with Inflammation in Head and Neck Cancer. Preprints 2024, 2024030034. https://doi.org/10.20944/preprints202403.0034.v1
Gusson-Zanetoni, J.P.; Cardoso, L.P.; De Sousa, S.O.; Silva, L.L.D.M.M.; Martinho, J.D.O.; Henrique, T.; Tajara, E.H.; Oliani, S.M.; Rodrigues-Lisoni, F.C. Molecular Aspects of Piperine in Signaling Pathways Associated with Inflammation in Head and Neck Cancer. Preprints2024, 2024030034. https://doi.org/10.20944/preprints202403.0034.v1
APA Style
Gusson-Zanetoni, J.P., Cardoso, L.P., De Sousa, S.O., Silva, L.L.D.M.M., Martinho, J.D.O., Henrique, T., Tajara, E.H., Oliani, S.M., & Rodrigues-Lisoni, F.C. (2024). Molecular Aspects of Piperine in Signaling Pathways Associated with Inflammation in Head and Neck Cancer. Preprints. https://doi.org/10.20944/preprints202403.0034.v1
Chicago/Turabian Style
Gusson-Zanetoni, J.P., Sonia Maria Oliani and Flávia Cristina Rodrigues-Lisoni. 2024 "Molecular Aspects of Piperine in Signaling Pathways Associated with Inflammation in Head and Neck Cancer" Preprints. https://doi.org/10.20944/preprints202403.0034.v1
Abstract
Piperine, an active plant alkaloid from black pepper (Piper nigrum), has several pharmacological effects: antioxidant, anti-inflammatory and immunomodulatory, which involves inhibiting molec-ular events associated with various stages of cancer development. The aim of this study was to investigate the molecular mechanisms of action of piperine in relation to its potential anticancer effect on head and neck cancer cells. Parameters related to neoplastic potential, analysis of cyto-kine, protein and gene expression were investigated in the head and neck cancer cell lines (HEp-2 and SCC-25) treated with piperine. The results of the tests indicated that piperine modified mor-phology, inhibited viability and the formation of cell colonies. Piperine promoted genotoxicity by triggering apoptosis and cell cycle arrest in G2/M and S. A decrease in cell migration was also observed, and decreased expression of MMP2/9 genes. Piperine also reduced the expression of inflammatory molecules (PTGS2 and PTGER4), regulated the secretion of cytokines (IF-y and IL-8) and modulated the expression of ERK and p38. These results suggest that piperine exerts anti-cancer effects on tumor cells, and could be a promising natural treatment by regulating signaling pathways associated with head and neck cancer.
Biology and Life Sciences, Biochemistry and Molecular Biology
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.