Version 1
: Received: 28 February 2024 / Approved: 29 February 2024 / Online: 29 February 2024 (09:59:43 CET)
How to cite:
Wang, Y.; Li, Z.; Wu, Y.; Zhao, G.; Cheng, Y.; Feng, K.; Yin, S. Analysis of Factors Related to the Efficacy of Consciousness-Regaining Therapy for Prolonged Disorder of consciousness:A Retrospective Cohort Study. Preprints2024, 2024021685. https://doi.org/10.20944/preprints202402.1685.v1
Wang, Y.; Li, Z.; Wu, Y.; Zhao, G.; Cheng, Y.; Feng, K.; Yin, S. Analysis of Factors Related to the Efficacy of Consciousness-Regaining Therapy for Prolonged Disorder of consciousness:A Retrospective Cohort Study. Preprints 2024, 2024021685. https://doi.org/10.20944/preprints202402.1685.v1
Wang, Y.; Li, Z.; Wu, Y.; Zhao, G.; Cheng, Y.; Feng, K.; Yin, S. Analysis of Factors Related to the Efficacy of Consciousness-Regaining Therapy for Prolonged Disorder of consciousness:A Retrospective Cohort Study. Preprints2024, 2024021685. https://doi.org/10.20944/preprints202402.1685.v1
APA Style
Wang, Y., Li, Z., Wu, Y., Zhao, G., Cheng, Y., Feng, K., & Yin, S. (2024). Analysis of Factors Related to the Efficacy of Consciousness-Regaining Therapy for Prolonged Disorder of consciousness:A Retrospective Cohort Study. Preprints. https://doi.org/10.20944/preprints202402.1685.v1
Chicago/Turabian Style
Wang, Y., Keke Feng and Shao-Ya Yin. 2024 "Analysis of Factors Related to the Efficacy of Consciousness-Regaining Therapy for Prolonged Disorder of consciousness:A Retrospective Cohort Study" Preprints. https://doi.org/10.20944/preprints202402.1685.v1
Abstract
To explore the relevant factors that affect the efficacy of consciousness-regaining therapy (CRT)for prolonged disorder of consciousness(pDOC),a retrospective analysis was conducted on the case data of 114 patients with pDOC admitted to department of functional neurosurgery of Tianjin Huanhu Hospital from January 2019 to January 2022. Basic information on the cases,data on pDOC disease assessment, consciousness-regaining therapy methods, and efficacy evaluation were collected. A total of 114 patients were grouped and compared based on the efficacy at the end of treatment. Among them, there were 61 cases in the ineffective group and 53 cases in the effective group. There was no statistically significant difference (P>0.05) between the two groups in terms of gender, age, etiology, acute cerebral herniation, emergency craniotomy surgery, emergency decompressive craniectomy, time from onset to start of consciousness-regaining therapy , and duration of consciousness-regaining therapy(P>0.05). However, there were statistically significant differences (P<0.05) in terms of secondary hydrocephalus, , consciousness-regaining therapy methods, CRS-R grading before treatment, and GOSE score at 6 months after treatment. Binary logistic regression analysis showed that the type of therapy (OR=0.169, 95% CI: 0.057-0.508) was a related factor affecting the efficacy of consciousness-regaining therapy (P<0.05).Compared with non-invasive therapy, personalized awakening therapy using various invasive consciousness-regaining therapy methods can help improve the efficacy of therapy for pDOC.
Keywords
prolonged disorder of consciousness; consciousness-regaining therapy; recovery; factors; efficacy
Subject
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
