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Type 2 Hypersensitivity Disorders including Systemic Lupus Erythematosus, Sjogren’s Syndrome, Grave’s Disease, Myasthenia Gravis, Immune Thrombocytopenia, Autoimmune Hemolytic Anemia, Dermatomyositis, and Graft versus Host Disease Are THab Dominant A
Version 1
: Received: 23 February 2024 / Approved: 28 February 2024 / Online: 28 February 2024 (13:48:04 CET)
How to cite:
Hu, W. Type 2 Hypersensitivity Disorders including Systemic Lupus Erythematosus, Sjogren’s Syndrome, Grave’s Disease, Myasthenia Gravis, Immune Thrombocytopenia, Autoimmune Hemolytic Anemia, Dermatomyositis, and Graft versus Host Disease Are THab Dominant A. Preprints2024, 2024021614. https://doi.org/10.20944/preprints202402.1614.v1
Hu, W. Type 2 Hypersensitivity Disorders including Systemic Lupus Erythematosus, Sjogren’s Syndrome, Grave’s Disease, Myasthenia Gravis, Immune Thrombocytopenia, Autoimmune Hemolytic Anemia, Dermatomyositis, and Graft versus Host Disease Are THab Dominant A. Preprints 2024, 2024021614. https://doi.org/10.20944/preprints202402.1614.v1
Hu, W. Type 2 Hypersensitivity Disorders including Systemic Lupus Erythematosus, Sjogren’s Syndrome, Grave’s Disease, Myasthenia Gravis, Immune Thrombocytopenia, Autoimmune Hemolytic Anemia, Dermatomyositis, and Graft versus Host Disease Are THab Dominant A. Preprints2024, 2024021614. https://doi.org/10.20944/preprints202402.1614.v1
APA Style
Hu, W. (2024). <strong></strong>Type 2 Hypersensitivity Disorders including Systemic Lupus Erythematosus, Sjogren’s Syndrome, Grave’s Disease, Myasthenia Gravis, Immune Thrombocytopenia, Autoimmune Hemolytic Anemia, Dermatomyositis, and Graft versus Host Disease Are THab Dominant A. Preprints. https://doi.org/10.20944/preprints202402.1614.v1
Chicago/Turabian Style
Hu, W. 2024 "<strong></strong>Type 2 Hypersensitivity Disorders including Systemic Lupus Erythematosus, Sjogren’s Syndrome, Grave’s Disease, Myasthenia Gravis, Immune Thrombocytopenia, Autoimmune Hemolytic Anemia, Dermatomyositis, and Graft versus Host Disease Are THab Dominant A" Preprints. https://doi.org/10.20944/preprints202402.1614.v1
Abstract
Systemic lupus erythematosus (SLE) is a prevalent autoimmune condition, yet its alignment with a specific host immunological pathway remains unclear. The THαβ host immunological pathway, recognized for its defense against viruses and prions, has recently emerged as a response to DNA, RNA, and protein pathogens. SLE patients often produce anti-double strand DNA antibodies and anti-nuclear antibodies, suggesting a potential association with the THαβ host immune reaction. Throughout the course of SLE, elevated levels of type 1 interferons, type 3 interferons, interleukin-10, IgG1, and IgA1 are commonly observed. These cytokines and antibody isotypes are indicative of the THαβ host immunological pathway. Similarly, Myasthenia gravis, Grave’s disease, Graft versus host disease, autoimmune hemolytic anemia, immune thrombocytopenia, dermatomyositis, and Sjogren’s syndrome are also linked to THαβ-related type 2 hypersensitivities. Considering the potential association of these diseases with dysregulated THαβ immune responses, therapeutic strategies such as anti-interleukin-10 or anti-interferons α/β could be explored to manage these disorders effectively.
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
