Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

An overview of Monkeypox Virus: Molecular Biology, Epidemiology, Pathogenesis, Treatment and Prevention Strategies

Version 1 : Received: 24 February 2024 / Approved: 26 February 2024 / Online: 26 February 2024 (12:09:39 CET)

How to cite: Hussain, N.; Ashraf, M.H.; Arooj, R.; Arif, I.; Haqqi, R. An overview of Monkeypox Virus: Molecular Biology, Epidemiology, Pathogenesis, Treatment and Prevention Strategies. Preprints 2024, 2024021430. https://doi.org/10.20944/preprints202402.1430.v1 Hussain, N.; Ashraf, M.H.; Arooj, R.; Arif, I.; Haqqi, R. An overview of Monkeypox Virus: Molecular Biology, Epidemiology, Pathogenesis, Treatment and Prevention Strategies. Preprints 2024, 2024021430. https://doi.org/10.20944/preprints202402.1430.v1

Abstract

Monkeypox virus belongs to the Orthopoxvirus genus, which belongs to the Poxviridae family. The Monkeypox virus is responsible to cause monkeypox, a developing zoonotic disease that has been identified as the most common orthopoxvirus infection in humans in the post-eradication era of smallpox. The virus can be transmitted by a variety of animals, including monkeys and rodents as well as person-to-person. Monkeypox has a clinical presentation that is quite similar to smallpox but mortality is low, in that the febrile prodrome is followed by a period of skin eruption. Monkeypox cases have extended outside the forests of central Africa, where they were first discovered, to other regions of the globe, where they have been imported. This pattern of transmission is most likely related to a global reduction in orthopoxvirus immunity following the discontinuation of smallpox vaccination in 1980, when smallpox was proclaimed eliminated. As a result, monkeypox might become the very common orthopoxvirus infection that affect humans. The emergence of epidemics outside of Africa emphasizes the disease's global significance. Increased monitoring and identification of monkeypox cases are critical tools for gaining a better knowledge of the disease's ever-changing epidemiology.

Keywords

Monkeypox virus; Orthopoxvirus; Epidemiology; Zoonotic sources; Diagnosis; Treatment

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

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