Pini, L.; Bagnasco, D.; Beghè, B.; Braido, F.; Cameli, P.; Caminati, M.; Caruso, C.; Crimi, C.; Guarnieri, G.; Latorre, M.; Menzella, F.; Micheletto, C.; Vianello, A.; Visca, D.; Bondi, B.; El Masri, Y.; Giordani, J.; Mastrototaro, A.; Maule, M.; Pini, A.; Piras, S.; Zappa, M.; Senna, G.; Spanevello, A.; Paggiaro, P.; Blasi, F.; Canonica, G.W.; on behalf of the SANI Study Group. Unlocking the Long-Term Effectiveness of Benralizumab in Severe Eosinophilic Asthma: A Three-Year Real-Life Study. J. Clin. Med.2024, 13, 3013.
Pini, L.; Bagnasco, D.; Beghè, B.; Braido, F.; Cameli, P.; Caminati, M.; Caruso, C.; Crimi, C.; Guarnieri, G.; Latorre, M.; Menzella, F.; Micheletto, C.; Vianello, A.; Visca, D.; Bondi, B.; El Masri, Y.; Giordani, J.; Mastrototaro, A.; Maule, M.; Pini, A.; Piras, S.; Zappa, M.; Senna, G.; Spanevello, A.; Paggiaro, P.; Blasi, F.; Canonica, G.W.; on behalf of the SANI Study Group. Unlocking the Long-Term Effectiveness of Benralizumab in Severe Eosinophilic Asthma: A Three-Year Real-Life Study. J. Clin. Med. 2024, 13, 3013.
Pini, L.; Bagnasco, D.; Beghè, B.; Braido, F.; Cameli, P.; Caminati, M.; Caruso, C.; Crimi, C.; Guarnieri, G.; Latorre, M.; Menzella, F.; Micheletto, C.; Vianello, A.; Visca, D.; Bondi, B.; El Masri, Y.; Giordani, J.; Mastrototaro, A.; Maule, M.; Pini, A.; Piras, S.; Zappa, M.; Senna, G.; Spanevello, A.; Paggiaro, P.; Blasi, F.; Canonica, G.W.; on behalf of the SANI Study Group. Unlocking the Long-Term Effectiveness of Benralizumab in Severe Eosinophilic Asthma: A Three-Year Real-Life Study. J. Clin. Med.2024, 13, 3013.
Pini, L.; Bagnasco, D.; Beghè, B.; Braido, F.; Cameli, P.; Caminati, M.; Caruso, C.; Crimi, C.; Guarnieri, G.; Latorre, M.; Menzella, F.; Micheletto, C.; Vianello, A.; Visca, D.; Bondi, B.; El Masri, Y.; Giordani, J.; Mastrototaro, A.; Maule, M.; Pini, A.; Piras, S.; Zappa, M.; Senna, G.; Spanevello, A.; Paggiaro, P.; Blasi, F.; Canonica, G.W.; on behalf of the SANI Study Group. Unlocking the Long-Term Effectiveness of Benralizumab in Severe Eosinophilic Asthma: A Three-Year Real-Life Study. J. Clin. Med. 2024, 13, 3013.
Abstract
Background: Severe eosinophilic asthma (SEA) represents a substantial global health burden. Benralizumab has been shown to restore good control of asthma. Robust data on benralizumab effectiveness over periods longer than 2 years are still scarce. Methods: This retrospective multicentric study was conducted on 108 Italian SEA patients treated with benralizumab for up to 36 months. Clinical outcomes were evaluated at 6, 12, 24 and 36 months. Partial and complete clinical remission (CR) were also assessed. Data were analysed either with descriptive statistics or using linear, logistic, and negative binomial mixed-effect regression models. Results: Benralizumab induced a persistent reduction in exacerbation rates (p
Keywords
severe eosinophilic asthma; benralizumab; effectiveness; long-term; clinical remission
Subject
Medicine and Pharmacology, Pulmonary and Respiratory Medicine
Copyright:
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