This version is not peer-reviewed.
Submitted:
22 February 2024
Posted:
23 February 2024
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Skin model | Commercial Name | Manufacture | Country | Method for manufacture | OECD |
---|---|---|---|---|---|
Epidermal skin | EpiSkinTM | L'Oréal | France | Epidermal reconstruction model cultured in collagen medium using epidermal keratinocytes from skin tissue removed by mammoplasty as seed cells; | TG 431; TG 439 |
EpiEthicTM RHE | L'Oréal | France | Epidermal reconstruction model seeded with epidermal keratinocytes from foreskin tissue and cultured in inert polycarbonate lipase medium | TG 431; TG 439 | |
epiCS® | Henkel | Germany | Epidermal reconstruction model seeded with epidermal keratinocytes from foreskin tissue and cultured in serum-free medium | TG 431; TG 439 | |
EpiDermTM | MatTek | America | Epidermal reconstruction model using epidermal keratinocytes from foreskin tissue as seed cells in serum-free medium | TG 431; TG 439; TG 498; Micronucleus assay under peer-review | |
LabCyteTM EPI-MODEL | J-TEC | Japan | Keratinocytes from neonatal foreskin and 3T3-J2 grown in an inert filter matrix and cultured using an air-liquid surface approach | TG 431; TG 439 | |
Skin+ | Sterlab | France | Human primary representative dermal keratinocytes were used as seed cells and cultured in an air-liquid surface approach | TG439 | |
KeraSkinTM | Biosolution | Korea | cultured with human primary keratinocytes as seed cells and 3T3 cells as trophectoderm | TG439 | |
Full skin | Phenion® FT | Henkel | Germany | Neonatal foreskin primary keratinocytes cultured in collagen scaffolding fibroblasts to form connective tissue as the basis of a multilayered epithelial cell layer cultured in air-liquid surface | Comet assay under peer-review |
Corneal Epithelium | SkinEthic™ HCE | L'Oréal | France | Corneal epithelial model without keratinization using cells from immortalized human corneal epithelial tissue as seed cells, cultured in air-liquid surface culture | TG492; TG492B |
EpiOcular™ | MatTek | France | Corneal epithelial model without corneal stroma, seeded with cells from neonatal foreskin epithelial tissue and cultured in air-liquid surface culture with serum-free DMEM (EGF, insulin, HYD, etc.). | TG 492 | |
LabCyteTM CORNEA-MODEL24 | J-TEC | Japan | Normal human corneal epithelial cells from Rocky Mountain Lions Eye Bank, USA | TG 492 | |
MCTT HCETM | Biosolution | Korea | Prepared from corneal epithelial cells from corneal limbal tissue remaining after corneal transplantation | TG 492 |
Country | Manufacturer | Commercial skin models | Manufacturer Information |
---|---|---|---|
China | BioCell | EpiKutisTM | Founded in 2014, started the development of 3D cells in the early 90 s with the support of tissue engineering research and development of the Fourth Military Medical University and the Xi'an Institute of Tissue Engineering and Regenerative Medicine |
French | L'Oréal | EpiSkinTM | EpiSkin was constructed in 1991 by Estelle Tinois-Tessonneaud et al. of Imedex and acquired by L'Oreal in April 1997. |
SkinEthicTM | SkinEthic was built in 1990 by Rodsy M, Clauss LC et al. It was originally part of SkinEthic, which was acquired by L'Oreal's Episkin in 2006. | ||
Sterlab | Skin+® | The Sterlab Group was founded in 1977 and focuses on the development and application of implantable medical devices. | |
Germany | Henkel | epiCS® | epiCS® was developed by SkinInVitro GmbH in Germany, acquired by Henkel in November 2020, and is now part of Phenion. |
Phenion® | Phenion® was developed by Henkel in cooperation with the Johann WoKgang Goethe University in Frankfurt and a group of professors through the public‒private partnership Phenion GmbH. in 2007, K.R. Mewes and M. Raus, among others, developed the Phenion® model. in January 2009, Phenion GmbH became part of the Henkel Group. | ||
America | MatTek | EpiDermTM | MatTek was founded in 1985 and Epiderm was launched in 1993. |
Korea | Biosolution | MCTT HCETM | Biosolution founded in 2000, KeraSkin™ launched in 2002, MCTT HCETM launched in 2008. |
KeraSkin™ | |||
Japan | J-TEC | LabCyteTM | J-TEC founded in 1999, LabCyteTM EPI-MODEL launched in 2005 |
Group Name | Standard No. | Standard Name | Release Date | Endpoint of the Evaluation | Skin Model | Manufacture |
---|---|---|---|---|---|---|
Shanghai Daily Chemistry Trade Association | T/SHRH 008—2018 | Cosmetics-In Vitro Skin Irritation Test Method (SIT) | 2018/12/10 | Safety-Skin irritation (SIT) | EpiKuis® | BioCell Biotech |
Shanghai Daily Chemistry Trade Association | T/SHRH 007—2018 | Cosmetics-In Vitro Skin Irritation Test Method (ET-50) | 2018/12/10 | Safety-Skin irritation (ET-50) | EpiKuis® | BioCell Biotech |
Shanghai Daily Chemistry Trade Association | T/SHRH 012—2018 | Cosmetics Eye Irritation test - In vitro Reconstructed human Cornea-like Epithelium (RhCE) test method | 2018/12/10 | Safety-Eye irritation | Reconstructed human Cornea-like Epithelium | Not specified |
Shanghai Daily Chemistry Trade Association | T/SHRH 009—2018 | Cosmetics -3D Skin Comet Assay | 2018/12/10 | Safety-Genotoxicity | Phenion®FT | Henkel |
Shanghai Daily Chemistry Trade Association | T/SHRH 024—2019 | Eye irritation test of cosmetics-In vitro reconstructed cornea model-Time to toxicity test method (ET50) | 2019/12/31 | Safety-Eye irritation (ET50) | BioOcullar® | BioCell Biotech |
Shanghai Daily Chemistry Trade Association | T/SHRH 022—2019 | Moisturizing efficacy test of cosmetics-In vitro reconstructed human skin test method | 2019/12/31 | Moisturizing efficacy | EpiKutis® | BioCell Biotech |
Shanghai Daily Chemistry Trade Association | T/SHRH 021—2019 | Cosmetics whitening efficacy test-In vitro Reconstructed human skin containing melanocytes test method | 2019/12/31 | Whitening efficacy | MelaKutis® | BioCell Biotech |
Shanghai Daily Chemistry Trade Association | T/SHRH 023—2019 | Skin barrier efficacy test of cosmetics -In vitro reconstructed human skin test method | 2019/12/31 | Skin barrier efficacy | EpiKutis® | BioCell Biotech |
ZheJiang Health Products & Cosmetics Industry Association | T/ZHCA 009—2019 | Method of skin irritation test in vitro for face cream cosmetic products-In vitro skin irritation test with reconstructed skin model | 2022/1/4 | Safety-Skin irritation | EpiKuis® RHE | BioCell Biotech |
ZheJiang Health Products & Cosmetics Industry Association | T/ZHCA 013—2021 | Method of eye irritation test in vitro for facial cleanser cosmetic products—In vitro eye irritation test with reconstructed human cornea-like epithelium model | 2022/1/4 | Safety-Eye irritation | BioOcullar® | BioCell Biotech |
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