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The Soluble Human Leukocyte Antigen-G Levels in Amniotic Fluid and Maternal Serum Correlate with the Feto-Placental Growth in Uncomplicated Pregnancies
Version 1
: Received: 18 February 2024 / Approved: 20 February 2024 / Online: 20 February 2024 (05:55:15 CET)
How to cite:
Vincze, M.; Sikovanyecz Jr., J.; Suranyi, A.; Foldesi, I.; Várbíró, S.; Németh, G.; Kozinszky, Z.; Sikovanyecz, J. The Soluble Human Leukocyte Antigen-G Levels in Amniotic Fluid and Maternal Serum Correlate with the Feto-Placental Growth in Uncomplicated Pregnancies. Preprints2024, 2024021091. https://doi.org/10.20944/preprints202402.1091.v1
Vincze, M.; Sikovanyecz Jr., J.; Suranyi, A.; Foldesi, I.; Várbíró, S.; Németh, G.; Kozinszky, Z.; Sikovanyecz, J. The Soluble Human Leukocyte Antigen-G Levels in Amniotic Fluid and Maternal Serum Correlate with the Feto-Placental Growth in Uncomplicated Pregnancies. Preprints 2024, 2024021091. https://doi.org/10.20944/preprints202402.1091.v1
Vincze, M.; Sikovanyecz Jr., J.; Suranyi, A.; Foldesi, I.; Várbíró, S.; Németh, G.; Kozinszky, Z.; Sikovanyecz, J. The Soluble Human Leukocyte Antigen-G Levels in Amniotic Fluid and Maternal Serum Correlate with the Feto-Placental Growth in Uncomplicated Pregnancies. Preprints2024, 2024021091. https://doi.org/10.20944/preprints202402.1091.v1
APA Style
Vincze, M., Sikovanyecz Jr., J., Suranyi, A., Foldesi, I., Várbíró, S., Németh, G., Kozinszky, Z., & Sikovanyecz, J. (2024). The Soluble Human Leukocyte Antigen-G Levels in Amniotic Fluid and Maternal Serum Correlate with the Feto-Placental Growth in Uncomplicated Pregnancies. Preprints. https://doi.org/10.20944/preprints202402.1091.v1
Chicago/Turabian Style
Vincze, M., Zoltan Kozinszky and János Sikovanyecz. 2024 "The Soluble Human Leukocyte Antigen-G Levels in Amniotic Fluid and Maternal Serum Correlate with the Feto-Placental Growth in Uncomplicated Pregnancies" Preprints. https://doi.org/10.20944/preprints202402.1091.v1
Abstract
Introduction: The trophoblast derived angiogenic factors are considered to play an important role in the pathophysiology of various complications of pregnancy. The aim of this study was to establish relationship between concentrations of soluble Human Leukocyte Antigen-G (sHLA-G) in maternal serum and amniotic fluid at 16-22 weeks of gestation and the sonographic measurements of the fetal and placental growth.
Materials and methods: sHLA-G in serum and amniotic fluid, as well as fetal biometric data and placental volume and perfusion indices were determined in 41 uncomplicated singleton pregnancies.
Results: The sHLA-G levels were unchanged both in amniotic fluid and in serum during mid-pregnancy. The sHLA-G level in serum correlated positively with amniotic sHLA-G level (β=0.63, p<0.01). Significant correlation was found between serum sHLA-G level and abdominal measurement (β=0.41, p<0.05) and estimated fetal weight (β=0.41, p<0.05). The amniotic sHLA-G level and placental perfusion (VI: β = -0.34, p<0.01 and VFI: β = -0.44, p<0.01, respectively) were negatively interrelated. A low amniotic sHLA-G level was significantly associated with nuchal translucency (r = -0.102, p<0.05).
Conclusions: sHLA-G assayed in amniotic fluid might be a potential indicator for placental function, whereas the sHLA-G level in serum can be a prognostic modality for feto-placental insufficiency.
Keywords
soluble Human Leukocyte Antigen-G; serum; amniotic fluid; fetus; placenta; sonography
Subject
Public Health and Healthcare, Other
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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