Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Evaluation of the Oral Microbiome before and after Treatments for Halitosis with Photodynamic Therapy and Probiotics – Pilot Study

Pamella de Barros Motta
,
Marcela Leticia Leal Gonçalves
,
Juliana Maria Altavista Sagretti Gallo
,
Ana Paula Taboada Sobral
ORCID logo ,
Lara Jansiski Motta
ORCID logo ,
Elaine Marcílio Santos
,
David José Casimiro de Andrade
,
Cinthya Cosme Gutierrez Duran
,
Kristianne Porta Santos Fernandes
,
Raquel Agnelli Mesquita-Ferrari
,
Anna Carolina Ratto Tempestine Horliana
ORCID logo ,
Sandra Kalil Bussadori
*
Version 1 : Received: 19 February 2024 / Approved: 19 February 2024 / Online: 19 February 2024 (16:13:30 CET)

How to cite: Motta, P.D.B.; Gonçalves, M.L.L.; Gallo, J.M.A.S.; Sobral, A.P.T.; Motta, L.J.; Santos, E.M.; Andrade, D.J.C.D.; Duran, C.C.G.; Fernandes, K.P.S.; Mesquita-Ferrari, R.A.; Horliana, A.C.R.T.; Bussadori, S.K. Evaluation of the Oral Microbiome before and after Treatments for Halitosis with Photodynamic Therapy and Probiotics – Pilot Study. Preprints 2024, 2024021072. https://doi.org/10.20944/preprints202402.1072.v1 Motta, P.D.B.; Gonçalves, M.L.L.; Gallo, J.M.A.S.; Sobral, A.P.T.; Motta, L.J.; Santos, E.M.; Andrade, D.J.C.D.; Duran, C.C.G.; Fernandes, K.P.S.; Mesquita-Ferrari, R.A.; Horliana, A.C.R.T.; Bussadori, S.K. Evaluation of the Oral Microbiome before and after Treatments for Halitosis with Photodynamic Therapy and Probiotics – Pilot Study. Preprints 2024, 2024021072. https://doi.org/10.20944/preprints202402.1072.v1

Abstract

Background: To compare photodynamic therapy 41 and the use of probiotics in reducing halitosis assessed through gas chromatography and microbiome analysis. Methods: Participants aged from 18 to 25 years, showing sulfide (SH2) ≥ 112 ppb on gas chromatography, were selected. They were divided into 4 treatment groups: Group 1 - Tongue Scraping; Group 2- Antimicrobial Photodynamic Therapy (aPDT); Group 3- Probiotics; Group 4- Antimicrobial Photodynamic Therapy (aPDT) and Probiotics. The halimetry process was performed before, immediately after the treatments, 7 days, 14 days and 30 days after the initial collection. The collections for later microbiological analysis were made along with the halimetry, for the microbiome analysis. Results: Treatment with aPDT or probiotics under these experimental conditions was not able to change the bacteria present in the biofilm of the tongue. Conclusions: More research is needed to know the behavior of the oral microbiome in the presence of halitosis and the effectiveness of new treatments.

Keywords

halitosis; microbiome; antimicrobial photodynamic therapy; probiotics.

Subject

Medicine and Pharmacology, Dentistry and Oral Surgery

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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