Review
Version 1
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Biomarkers of Brain Dysfunction in Perinatal Iron Deficiency
Version 1
: Received: 17 February 2024 / Approved: 18 February 2024 / Online: 19 February 2024 (10:28:17 CET)
A peer-reviewed article of this Preprint also exists.
Rao, R.B. Biomarkers of Brain Dysfunction in Perinatal Iron Deficiency. Nutrients 2024, 16, 1092. Rao, R.B. Biomarkers of Brain Dysfunction in Perinatal Iron Deficiency. Nutrients 2024, 16, 1092.
Abstract
Iron deficiency in the fetal and neonatal period (perinatal iron deficiency) bodes poorly to neuro-development. Given its common occurrence and the negative impact on brain development, a screening and treatment strategy that is focused on optimizing brain development in perinatal iron deficiency is necessary. Pediatric societies currently recommend a universal iron supple-mentation strategy for full-term and preterm infants that does not consider individual variation in the body iron status and could lead to under-treatment or over-treatment. Moreover, the focus is on hematological normalcy and not optimal brain development. Several serum iron indices and hematological parameters in the perinatal period are associated with risk of abnormal neurodevelopment, suggesting their potential use as biomarkers for screening and monitoring treatment in infants at risk for perinatal iron deficiency. A biomarker-based screening and treatment strategy that is focused on optimizing brain development will likely improve outcome in perinatal iron deficiency.
Keywords
biomarker; brain; ferritin; hemoglobin; iron; iron deficiency; neurodevelopment; perinatal; reticulocyte hemoglobin; zinc protoporphyrin-to-heme ratio
Subject
Medicine and Pharmacology, Clinical Medicine
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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