Preprint Communication Version 1 Preserved in Portico This version is not peer-reviewed

Could SP-A and SP-D Serum Levels Predict COVID-19 Severity?

Luca Maddaloni
* ORCID logo ,
Veronica Zullino
,
Ginevra Bugani
* ORCID logo ,
Alessandro Lazzaro
,
Matteo Brisciani
,
Claudio Mastroianni
ORCID logo ,
Letizia Santinelli
ORCID logo ,
Franco Ruberto
Version 1 : Received: 12 February 2024 / Approved: 13 February 2024 / Online: 13 February 2024 (13:06:34 CET)
Version 2 : Received: 19 April 2024 / Approved: 19 April 2024 / Online: 19 April 2024 (15:21:14 CEST)

How to cite: Maddaloni, L.; Zullino, V.; Bugani, G.; Lazzaro, A.; Brisciani, M.; Mastroianni, C.; Santinelli, L.; Ruberto, F. Could SP-A and SP-D Serum Levels Predict COVID-19 Severity?. Preprints 2024, 2024020739. https://doi.org/10.20944/preprints202402.0739.v1 Maddaloni, L.; Zullino, V.; Bugani, G.; Lazzaro, A.; Brisciani, M.; Mastroianni, C.; Santinelli, L.; Ruberto, F. Could SP-A and SP-D Serum Levels Predict COVID-19 Severity?. Preprints 2024, 2024020739. https://doi.org/10.20944/preprints202402.0739.v1

Abstract

Given the various clinical manifestations that characterize COVID-19, the scientific community is constantly searching for biomarkers with prognostic value. SP-A and SP-D collectins play a crucial role in ensuring proper alveolar function and an alteration of their serum levels have been reported in several pulmonary diseases characterized by ARDS and pulmonary fibrosis. Considering that such clinical manifestations can also occur during SARS-CoV-2 infection, we wondered if these collectins could act as prognostic markers. In this regard, serum levels of SP-A and SP-D were measured by enzyme immunoassay in patients with SARS-CoV-2 infection (n=51) at admission (T0) and after 7 days (T1) and compared with healthy donors (n=11). SP-D increased in COVID-19 patients compared to healthy controls during the early phases of infection, while a significant reduction was observed at T1. Stratifying SARS-CoV-2 patients according to disease severity, increased serum SP-D levels were observed in severe compared to mild patients. In the light of these results SP-D, but not SP-A, seems to be an eligible marker of COVID-19 pneumonia and the early detection of SP-D serum levels could be crucial for a preventive clinical management

Keywords

SP-A; SP-D; SARS-CoV-2; collectins; surfactant proteins

Subject

Biology and Life Sciences, Virology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.