Version 1
: Received: 11 February 2024 / Approved: 12 February 2024 / Online: 13 February 2024 (08:13:13 CET)
How to cite:
Ferrari, I.V. Investigating the Inhibitory Potential of Amentoflavone against HIV-1 Protease: A Molecular Docking Study. Preprints2024, 2024020696. https://doi.org/10.20944/preprints202402.0696.v1
Ferrari, I.V. Investigating the Inhibitory Potential of Amentoflavone against HIV-1 Protease: A Molecular Docking Study . Preprints 2024, 2024020696. https://doi.org/10.20944/preprints202402.0696.v1
Ferrari, I.V. Investigating the Inhibitory Potential of Amentoflavone against HIV-1 Protease: A Molecular Docking Study. Preprints2024, 2024020696. https://doi.org/10.20944/preprints202402.0696.v1
APA Style
Ferrari, I.V. (2024). Investigating the Inhibitory Potential of Amentoflavone against HIV-1 Protease: A Molecular Docking Study<strong> </strong>. Preprints. https://doi.org/10.20944/preprints202402.0696.v1
Chicago/Turabian Style
Ferrari, I.V. 2024 "Investigating the Inhibitory Potential of Amentoflavone against HIV-1 Protease: A Molecular Docking Study<strong> </strong>" Preprints. https://doi.org/10.20944/preprints202402.0696.v1
Abstract
This study investigates the potential of natural compounds against HIV-1 protease, a critical enzyme in the replication cycle of human immunodeficiency virus type 1 (HIV-1). HIV-1 protease is essential for cleaving large precursor proteins into smaller functional proteins necessary for viral maturation and infectivity. Protease inhibitors, specifically targeting HIV-1 protease, effectively suppress viral replication, aiding in the management of HIV infection. Using the SWISS DOCK Server, several natural compounds were investigated for their potential as inhibitors of HIV-1 protease. Docking results revealed that Amentoflavone showed excellent binding affinity with high Estimated ΔG values, suggesting its potential as an inhibitor of HIV-1 protease. Additionally, Amentoflavone exhibited similar promising results when tested against Roussarcoma virus protease. These findings indicate the potential of Amentoflavone as a natural compound against HIV and warrant further investigation into its therapeutic applications.
Keywords
HIV-1 protease 2; SWISS DOCK Server; Roussarcoma virus protease; Human Immunodeficiency Virus
Subject
Public Health and Healthcare, Other
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
