Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Anti-Obesity Effect and Signaling Mechanism of Potassium Poly-γ-Glutamate Produced by Bacillus subtilis Chungkookjang in a High-Fat Diet-Induced Obese Mice

Seung-Hyeon Lee
,
Jiwon Choi
,
Jae Young Park
,
Ha-Rim Kim
,
Myeongkuk Shim
,
Kyunghyun Im
,
Hyeonjeong Choe
,
Jae-Chul Choi
,
Young-Chul Park
,
Tae-Gyu Lim
ORCID logo ,
Hyangyim Seo
,
Hansu Jang
,
Boung-Jun Oh
,
Seon-Young Kim
* ORCID logo ,
Mi Hee Park
* ORCID logo
Version 1 : Received: 7 February 2024 / Approved: 8 February 2024 / Online: 8 February 2024 (09:51:31 CET)

A peer-reviewed article of this Preprint also exists.

Lee, S.-H.; Choi, J.; Park, J.Y.; Kim, H.-R.; Shim, M.; Im, K.; Choe, H.; Choi, J.-C.; Park, Y.-C.; Lim, T.-G.; Seo, H.; Jang, H.; Oh, B.-J.; Kim, S.-Y.; Park, M.H. Anti-Obesity Effect and Signaling Mechanism of Potassium Poly-γ-Glutamate Produced by Bacillus subtilis Chungkookjang in High-Fat Diet-Induced Obese Mice. Nutrients 2024, 16, 809. Lee, S.-H.; Choi, J.; Park, J.Y.; Kim, H.-R.; Shim, M.; Im, K.; Choe, H.; Choi, J.-C.; Park, Y.-C.; Lim, T.-G.; Seo, H.; Jang, H.; Oh, B.-J.; Kim, S.-Y.; Park, M.H. Anti-Obesity Effect and Signaling Mechanism of Potassium Poly-γ-Glutamate Produced by Bacillus subtilis Chungkookjang in High-Fat Diet-Induced Obese Mice. Nutrients 2024, 16, 809.

Abstract

This study aimed to investigate the effect of potassium poly-γ-glutamate (PGA-K) on mice fed a high-fat diet consisting of 60% of total calories for a duration of 12 weeks. PGA-K administration reduced the increase in body weight, epididymal fat, and liver weight caused by a high-fat diet compared to the obese group. The triglyceride, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol levels, which are blood lipid indicators, were significantly increased in the obese group but were significantly decreased in the PGA-K-treated group. The administration of PGA-K resulted in a significant inhibition of pro-inflammatory cytokines, including tumor necrosis factor α and interleukin 6. Moreover, the levels of leptin and insulin, which are insulin resistance indicators, significantly increased in the obese group but were significantly decreased in the PGA-K-treated group. These results suggest that PGA-K exhibits a protective effect against obesity induced by a high-fat diet, underscoring its potential as a candidate for obesity treatment.

Keywords

Potassium Poly-γ-glutamate; Chungkookjang; Obesity; Inflammation; Insulin resistance

Subject

Biology and Life Sciences, Food Science and Technology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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