Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Toxicological Response of Zebrafish Exposed to Cocktails of Polymeric Materials and Valproic Acid

Alexandra Savuca
ORCID logo ,
Alexandru Ionut Chelaru
* ORCID logo ,
Ioana-Miruna Balmus
,
Alexandrina-Ștefania Curpăn
ORCID logo ,
Mircea Nicusor Nicoara
* ORCID logo ,
Alin Ciobica
Version 1 : Received: 4 February 2024 / Approved: 5 February 2024 / Online: 5 February 2024 (13:52:40 CET)

A peer-reviewed article of this Preprint also exists.

Savuca, A.; Chelaru, I.-A.; Balmus, I.-M.; Curpan, A.-S.; Nicoara, M.N.; Ciobica, A.S. Toxicological Response of Zebrafish Exposed to Cocktails of Polymeric Materials and Valproic Acid. Sustainability 2024, 16, 2057. Savuca, A.; Chelaru, I.-A.; Balmus, I.-M.; Curpan, A.-S.; Nicoara, M.N.; Ciobica, A.S. Toxicological Response of Zebrafish Exposed to Cocktails of Polymeric Materials and Valproic Acid. Sustainability 2024, 16, 2057.

Abstract

Microplastic pollution represents an emerging problem of great interest in the public domain in the last decade; in addition, it overlaps with another delicate problem - pollution with pharmaceutical products that can have negative effects on the environment and people, even in small amounts. The main purpose of this study was to assess the biochemical and behavioral effects of exposure of adult zebrafish (Danio rerio) to polyethylene (PE), polypropylene (PP) and valproic acid (VPA), respectively to their mixtures - possible situations in natural aquatic environments. In terms of behavioral responses, sociability appears to be more impaired in the PP group after 5 days of exposure. The mechanisms affected are more those of swimming performance than of sociability. Even more, VPA increases presence in the arm with conspecifics but decreases mobility and locomotion, indicating a possible anxiety mechanism. The mixtures decrease the aggressiveness, especially in the case of the PE+VPA group, where it reaches a super low level compared to the control, which could endanger the species in nature. Regarding the anxiogenic effect, PP and PE act differently, if PE has an anxiogenic effect, on the opposite side is the PP group, which shows a bolder and more agitated behavior. All four variants showed behavioral changes indicative of toxicity from the first dose.

Keywords

microplastics, valproic acid, zebrafish, toxicity assessment.

Subject

Biology and Life Sciences, Behavioral Sciences

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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