Version 1
: Received: 3 February 2024 / Approved: 5 February 2024 / Online: 5 February 2024 (07:29:03 CET)
How to cite:
Făgărășan, A.; Ghiragosian-Rusu, S.; Toma, D.; Chincesean, M.; Andreea, C.; Gozar, L.; Sasaran, M.O. Multimodale Echocardiographic Evaluation for Early Detection of Cardiotoxicity Induced by Chemotherapy in Childhood Cancer. Preprints2024, 2024020225. https://doi.org/10.20944/preprints202402.0225.v1
Făgărășan, A.; Ghiragosian-Rusu, S.; Toma, D.; Chincesean, M.; Andreea, C.; Gozar, L.; Sasaran, M.O. Multimodale Echocardiographic Evaluation for Early Detection of Cardiotoxicity Induced by Chemotherapy in Childhood Cancer. Preprints 2024, 2024020225. https://doi.org/10.20944/preprints202402.0225.v1
Făgărășan, A.; Ghiragosian-Rusu, S.; Toma, D.; Chincesean, M.; Andreea, C.; Gozar, L.; Sasaran, M.O. Multimodale Echocardiographic Evaluation for Early Detection of Cardiotoxicity Induced by Chemotherapy in Childhood Cancer. Preprints2024, 2024020225. https://doi.org/10.20944/preprints202402.0225.v1
APA Style
Făgărășan, A., Ghiragosian-Rusu, S., Toma, D., Chincesean, M., Andreea, C., Gozar, L., & Sasaran, M.O. (2024). Multimodale Echocardiographic Evaluation for Early Detection of Cardiotoxicity Induced by Chemotherapy in Childhood Cancer. Preprints. https://doi.org/10.20944/preprints202402.0225.v1
Chicago/Turabian Style
Făgărășan, A., Liliana Gozar and Maria Oana Sasaran. 2024 "Multimodale Echocardiographic Evaluation for Early Detection of Cardiotoxicity Induced by Chemotherapy in Childhood Cancer" Preprints. https://doi.org/10.20944/preprints202402.0225.v1
Abstract
Cardiotoxicity remains one of the leading causes of morbidity and mortality in childhood cancer survivors. This study aimed to evaluate cardiotoxic side effects of chemotherapeutic regimens in a pediatric population, as revealed by assessment of baseline end-of-treatment and in follow-up after 1 year. A prospective study was conducted on 39 children, enrolled over a period of 5 years (2017-2022), diagnosed with leukemia and receiving chemotherapy regimens. A multimodal echocardiographic evaluation was done (two-dimensional echocardiography and M-mode, tissue doppler imaging (TDI) and 2D-speckle tracking (2DST) before the initiation of the cytostatic treatment, at the end of the treatment and 1 year after the treatment. Ultrasound-derived parameter values were compared between evaluations and correlated with cumulative doses of chemotherapeutic agents used. There were no significant differences in mean values for any of the imagistic parameters analyzed. However, a significant correlation was found between E’value percentage variation and cumulative dose of both anthracyclines and antimetabolics administered (p=0.03). Moreover, a significant linear regression correlation was found between alkylating agent dose and global longitudinal strain (GLS)(p<0.01). Non-invasive cardiovascular imaging parameter values did not differ significantly from baseline in our study, but some of them seem to be dependent upon cumulative dose of cytostatic agents used. Further studies on larger populations and involving a longer follow-up period might provide more insight into cardiotoxicity of chemotherapy regimens.
Keywords
echocardiography; speckle-tracking; cardiotoxicity; chemotherapy; children
Subject
Public Health and Healthcare, Public Health and Health Services
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
,
,
,
,
*
