Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

First Report of the Emerging Pathogen Kodamaea ohmeri in Honduras

Bryan Ortiz
,
Roque López
,
Carlos Muñóz
,
Kateryn Aguilar
,
Fernando Pérez
ORCID logo ,
Isis Laínez-Arteaga
,
Fernando Chávez
,
Celeste Galindo
,
Luis Rivera
ORCID logo ,
Manuel G Ballesteros-Monrreal
,
Pablo Mendez-Pfeiffer
ORCID logo ,
Dora Valencia
ORCID logo ,
Gustavo Fontecha
* ORCID logo
Version 1 : Received: 31 January 2024 / Approved: 1 February 2024 / Online: 1 February 2024 (08:35:19 CET)

A peer-reviewed article of this Preprint also exists.

Ortiz, B.; López, R.; Muñoz, C.; Aguilar, K.; Pérez, F.; Laínez-Arteaga, I.; Chávez, F.; Galindo, C.; Rivera, L.; Ballesteros-Monrreal, M.G.; Méndez-Pfeiffer, P.; Valencia, D.; Fontecha, G. First Report of the Emerging Pathogen Kodamaea ohmeri in Honduras. J. Fungi 2024, 10, 186. Ortiz, B.; López, R.; Muñoz, C.; Aguilar, K.; Pérez, F.; Laínez-Arteaga, I.; Chávez, F.; Galindo, C.; Rivera, L.; Ballesteros-Monrreal, M.G.; Méndez-Pfeiffer, P.; Valencia, D.; Fontecha, G. First Report of the Emerging Pathogen Kodamaea ohmeri in Honduras. J. Fungi 2024, 10, 186.

Abstract

Kodamaea ohmeri is an environmental yeast considered a rare emerging pathogen. In clinical settings, the correct identification of this yeast is relevant since some isolates are associated with resistance to antifungals. There is a lack of available data regarding the geographical distribution, virulence, and drug resistance profile of K. ohmeri. To contribute to the knowledge of this yeast, this study aimed to describe in depth three isolates of K. ohmeri associated with fungemia in Honduras. The identification of the isolates was carried out by sequencing the ribosomal ITS region. In addition, the sensitivity profile to antifungals was determined, and some properties associated with virulence were evaluated (exoenzyme production, biofilm formation, cell adhesion, and invasion). The isolates showed strong protease, phospholipase, and hemolysin activity, in addition to being biofilm producers. Adherence and invasion capacity were evident in the HeLa and Raw 264.7 cell lines respectively. This study expands the understanding of the underlying biological traits associated with virulence in K. ohmeri and is the first report of the detection and identification of K. ohmeri in Honduras as a cause of human infection.

Keywords

Kodamaea ohmeri; Honduras; virulence; diagnosis; adhesion; macrophages

Subject

Biology and Life Sciences, Immunology and Microbiology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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