Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Palmitic Acid Inhibits Cell Proliferation and Tumor Growth of Endometrial Cancer In Vitro and In Vivo

Ziyi Zhao
,
Jiandong Wang
,
Weimin Kong
,
Meredith Anne Newton
,
Wesley Burkett
,
Wenchuan Sun
,
Lindsey Buckingham
,
Jillian Donnell
,
Hongyan Suo
,
Boer Deng
,
Xiaochang Shen
,
Xin Zhang
,
Tianran Hao
,
Chunxiao Zhou
* ,
Victoria Bae-Jump
*
Version 1 : Received: 30 January 2024 / Approved: 31 January 2024 / Online: 31 January 2024 (10:56:35 CET)

How to cite: Zhao, Z.; Wang, J.; Kong, W.; Newton, M.A.; Burkett, W.; Sun, W.; Buckingham, L.; Donnell, J.; Suo, H.; Deng, B.; Shen, X.; Zhang, X.; Hao, T.; Zhou, C.; Bae-Jump, V. Palmitic Acid Inhibits Cell Proliferation and Tumor Growth of Endometrial Cancer In Vitro and In Vivo. Preprints 2024, 2024012205. https://doi.org/10.20944/preprints202401.2205.v1 Zhao, Z.; Wang, J.; Kong, W.; Newton, M.A.; Burkett, W.; Sun, W.; Buckingham, L.; Donnell, J.; Suo, H.; Deng, B.; Shen, X.; Zhang, X.; Hao, T.; Zhou, C.; Bae-Jump, V. Palmitic Acid Inhibits Cell Proliferation and Tumor Growth of Endometrial Cancer In Vitro and In Vivo. Preprints 2024, 2024012205. https://doi.org/10.20944/preprints202401.2205.v1

Abstract

Epidemiological and clinical evidence have extensively documented the role of obesity in the develop-ment of endometrial cancer. However, the effect of fatty acids on cell growth in endometrial cancer has not been widely studied. Here we reported that palmitic acid significantly inhibited cell proliferation of endometrial cancer cells and primary cultures of endometrial cancer, and reduced tumor growth in a transgenic mouse model of endometrial cancer, in parallel with increased cellular stress and apoptosis and decreased cellular adhesion and invasion. Inhibition of cellular stress by N-acetyl-L-cysteine effec-tively reversed the effects of palmitic acid on cell proliferation, apoptosis and invasive capacity in the endometrial cancer cells. Palmitic acid increased the intracellular formation of lipid droplets in a time- and dose-dependent manner. Depletion of lipid droplets by blocking DGAT1 and DGAT2 effectively increased the ability of palmitic acid to inhibit cell proliferation and induce cleaved caspase 3 activity. Collectively, this study provides new insight into the effect of palmitic acid on cell proliferation, inva-sion and the formation of lipid droplets that may have potential clinical relevance in the treatment of obesity-driven endometrial cancer

Keywords

palmitic acid; endometrial cancer; lipid droplet; apoptosis; invasion; cellular stress 

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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