Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Clinically Effective Molecules of Natural Origin for Obesity Prevention or Treatment

Gladys Maribel Hidalgo-Lozada
ORCID logo ,
Angelica Villarruel-López
ORCID logo ,
Karla Nuño
,
Abel García-García
,
Yaír Adonaí Sánchez-Nuño
* ORCID logo ,
César Octavio Ramos-García
* ORCID logo
Version 1 : Received: 30 January 2024 / Approved: 31 January 2024 / Online: 31 January 2024 (07:28:43 CET)

A peer-reviewed article of this Preprint also exists.

Hidalgo-Lozada, G.M.; Villarruel-López, A.; Nuño, K.; García-García, A.; Sánchez-Nuño, Y.A.; Ramos-García, C.O. Clinically Effective Molecules of Natural Origin for Obesity Prevention or Treatment. Int. J. Mol. Sci. 2024, 25, 2671. Hidalgo-Lozada, G.M.; Villarruel-López, A.; Nuño, K.; García-García, A.; Sánchez-Nuño, Y.A.; Ramos-García, C.O. Clinically Effective Molecules of Natural Origin for Obesity Prevention or Treatment. Int. J. Mol. Sci. 2024, 25, 2671.

Abstract

The prevalence and incidence of obesity and the comorbidities linked to it are increasing in the world population. Current therapies for obesity and associated pathologies have proven to cause a broad number of adverse effects and often, they are overpriced or not affordable for all patients. Among the alternatives currently available, natural bioactive compounds stand out. These are frequently contained in pharmaceutical presentations, nutraceutical products, supplements, or functional foods. The clinical evidence for these molecules is increasingly solid, among which epigallocatechin-3-gallate, ellagic acid, resveratrol, berberine, anthocyanins, probiotics, carotenoids, curcumin, silymarin, hydroxy citric acid, and α-lipoic acid stand out. The molecular mechanisms and signaling pathways of these molecules have been shown to interact with the endocrine, nervous, and gastroenteric systems, as well as regulate the expression of multiple genes and, therefore, proteins involved in starvation-satiety processes, activation of brown adipose tissue, increased lipolysis, decreased lipogenesis, and inflammation, beneficial changes in metabolism and improved insulin sensitivity. This review provides a comprehensive view of nature-based therapeutic options to address the increasing prevalence of obesity. It offers a valuable perspective for future research and subsequent clinical practice, addressing everything from the molecular, genetic, and physiological bases to the clinical study of the bioactive compound.

Keywords

natural compounds; functional foods; carotenoids; resveratrol; ellagic acid; berberine; probiotics; obesity; treatment; cardiovascular risk factors

Subject

Public Health and Healthcare, Primary Health Care

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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