Bottlenecks in the Investigation of Retinal Sterol Homeostasis

Sriganesh Ramachandra Rao; Steven J. Fliesler

doi:10.20944/preprints202401.2146.v2

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preprints.org > biology and life sciences > biochemistry and molecular biology > doi: 10.20944/preprints202401.2146.v2

Preprint Review Version 2 Preserved in Portico This version is not peer-reviewed

Bottlenecks in the Investigation of Retinal Sterol Homeostasis

Sriganesh Ramachandra Rao

^* and

Steven J. Fliesler

Version 1 : Received: 30 January 2024 / Approved: 30 January 2024 / Online: 31 January 2024 (08:32:29 CET)
Version 2 : Received: 9 February 2024 / Approved: 13 February 2024 / Online: 14 February 2024 (09:57:11 CET)

A peer-reviewed article of this Preprint also exists.

Ramachandra Rao, S.; Fliesler, S.J. Bottlenecks in the Investigation of Retinal Sterol Homeostasis. Biomolecules 2024, 14, 341. Ramachandra Rao, S.; Fliesler, S.J. Bottlenecks in the Investigation of Retinal Sterol Homeostasis. Biomolecules 2024, 14, 341.

Abstract

Sterol homeostasis in mammalian cells and tissues involves balancing three fundamental processes: de novo sterol biosynthesis; sterol import (e.g., from blood-borne lipoproteins); and sterol export. In complex tissues, composed of multiple different cell types (such as the retina), import and export also may involve intra-tissue, inter-cellular sterol exchange. Disruption of any of these processes can result in pathologies that impact the normal structure and function of the retina. Here, we provide a brief overview of what is known currently about sterol homeostasis in the vertebrate retina and offer a proposed path for future experimental work to further our understanding of these processes, with relevance to the development of novel therapeutic interventions for human diseases involving defective sterol homeostasis.

Keywords

cholesterol; homeostasis; lipid; lipoprotein; retina; retinal degeneration; sterol

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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