Version 1
: Received: 24 January 2024 / Approved: 24 January 2024 / Online: 24 January 2024 (14:22:26 CET)
How to cite:
Pusceddu, C.; Rinaldi, P.; Cappucci, M.; Cau, C.; Melis, L.; Faiella, E.; Marsico, S. Evaluating the Effectiveness of CT-Guided Cryoablation in Treating Adrenal Metastases: Insights from a Single-Center Study. Preprints2024, 2024011762. https://doi.org/10.20944/preprints202401.1762.v1
Pusceddu, C.; Rinaldi, P.; Cappucci, M.; Cau, C.; Melis, L.; Faiella, E.; Marsico, S. Evaluating the Effectiveness of CT-Guided Cryoablation in Treating Adrenal Metastases: Insights from a Single-Center Study. Preprints 2024, 2024011762. https://doi.org/10.20944/preprints202401.1762.v1
Pusceddu, C.; Rinaldi, P.; Cappucci, M.; Cau, C.; Melis, L.; Faiella, E.; Marsico, S. Evaluating the Effectiveness of CT-Guided Cryoablation in Treating Adrenal Metastases: Insights from a Single-Center Study. Preprints2024, 2024011762. https://doi.org/10.20944/preprints202401.1762.v1
APA Style
Pusceddu, C., Rinaldi, P., Cappucci, M., Cau, C., Melis, L., Faiella, E., & Marsico, S. (2024). Evaluating the Effectiveness of CT-Guided Cryoablation in Treating Adrenal Metastases: Insights from a Single-Center Study. Preprints. https://doi.org/10.20944/preprints202401.1762.v1
Chicago/Turabian Style
Pusceddu, C., Eliodoro Faiella and Salvatore Marsico. 2024 "Evaluating the Effectiveness of CT-Guided Cryoablation in Treating Adrenal Metastases: Insights from a Single-Center Study" Preprints. https://doi.org/10.20944/preprints202401.1762.v1
Abstract
Background:
To assess effectiveness, safety of computed tomography (CT)-guided cryoablation for treating adrenal metastases (AMs).
Materials and Methods:
This study involved 12 patients treated with 13 CT-guided cryoablation procedures for AMs between 2016 and 2020.
Patients’ ineligible for surgery, with tumors ≤5 cm, and no significant health risks were included. The procedures, conducted by expert radiologists, included initial non-contrast CT scans to determine lesion morphology, followed by cryoablation with monitoring for complications.
Post-treatment, patients underwent regular physical and laboratory checks, including hormonal analysis, and CT scans at specified intervals to assess the treatment's effectiveness and detect disease recurrence or progression.
Results:
In this study, 12 patients with AMs successfully underwent cryoablation, achieving a primary technical success rate of 91.7% and a secondary rate of 100% after a repeat procedure for one patient.
All cryoablation sessions were completed without major complications, with ice ball formations extending 1 cm beyond tumor margins to ensure safety.
Over an 8–24-month follow-up (average 16.3 months), six patients required further systemic therapy, with three developing extra-adrenal tumors. Local progression was noted in two patients (16.7%), one of whom underwent a repeat cryoablation.
Systemic progression was observed in five patients, involving renal and NSCLC cancer recurrences and bone metastasis.
The study reported five deaths due to tumor progression and heart failure, with an average overall survival duration of 32.4 ± 7.6 months.
Keywords
adrenal metastases, computed tomography, cryoablation, lesion control
Subject
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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