Harnessing NKG2D CAR-T Cell Therapy to Target Solid Tumors: Advancements and Applications

Vitaly Chasov; Albert Rizvanov

doi:10.20944/preprints202401.1661.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 19 January 2024 / Approved: 23 January 2024 / Online: 23 January 2024 (07:43:32 CET)

Here we explore the emerging role of NKG2D CAR-T cell therapy in the realm of solid tumor treatment. Unique capabilities of NKG2D CAR-T cells to recognize stress-induced ligands on cancer cells are discussed, highlighting the therapy's potential for targeted and precise antitumor responses. We also examine the challenges and opportunities associated with NKG2D CAR-T cell therapy, emphasizing the ongoing advancements and clinical trial progress shaping its future. Ultimately, the discussion underscores the transformative promise of NKG2D CAR-T cell therapy in revolutionizing the landscape of solid tumor treatment and enhancing the prospects for improved patient outcomes.

Immunotherapy; cell therapy; CAR-T cells; chimeric antigen receptor; NKG2D

Biology and Life Sciences, Cell and Developmental Biology

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Harnessing NKG2D CAR-T Cell Therapy to Target Solid Tumors: Advancements and Applications

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