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Prognostic Factors Associated with Tumor Recurrence and Overall Survival in Soft Tissue Sarcomas of the Extremities in a Colombian Reference Cancer Center
Díaz Casas, S.E.; Villacrés, J.M.; Lehmann Mosquera, C.; García Mora, M.; Mariño Lozano, I.; Ángel Aristizábal, J.; Suarez Rodríguez, R.; Torres, C.A.D.; Sánchez Pedraza, R. Prognostic Factors Associated with Tumor Recurrence and Overall Survival in Soft Tissue Sarcomas of the Extremities in a Colombian Reference Cancer Center. Curr. Oncol.2024, 31, 1725-1738.
Díaz Casas, S.E.; Villacrés, J.M.; Lehmann Mosquera, C.; García Mora, M.; Mariño Lozano, I.; Ángel Aristizábal, J.; Suarez Rodríguez, R.; Torres, C.A.D.; Sánchez Pedraza, R. Prognostic Factors Associated with Tumor Recurrence and Overall Survival in Soft Tissue Sarcomas of the Extremities in a Colombian Reference Cancer Center. Curr. Oncol. 2024, 31, 1725-1738.
Díaz Casas, S.E.; Villacrés, J.M.; Lehmann Mosquera, C.; García Mora, M.; Mariño Lozano, I.; Ángel Aristizábal, J.; Suarez Rodríguez, R.; Torres, C.A.D.; Sánchez Pedraza, R. Prognostic Factors Associated with Tumor Recurrence and Overall Survival in Soft Tissue Sarcomas of the Extremities in a Colombian Reference Cancer Center. Curr. Oncol.2024, 31, 1725-1738.
Díaz Casas, S.E.; Villacrés, J.M.; Lehmann Mosquera, C.; García Mora, M.; Mariño Lozano, I.; Ángel Aristizábal, J.; Suarez Rodríguez, R.; Torres, C.A.D.; Sánchez Pedraza, R. Prognostic Factors Associated with Tumor Recurrence and Overall Survival in Soft Tissue Sarcomas of the Extremities in a Colombian Reference Cancer Center. Curr. Oncol. 2024, 31, 1725-1738.
Abstract
Introduction:
Soft tissue sarcomas (STS) are low-incidence tumors whose clinical and histopathological factors are associated with adverse oncological outcomes. This study evaluated prognostic factors (PF) associated with tumor recurrence and overall survival (OS) in patients diagnosed with STS of the extremities, treated at the Instituto Nacional de Cancerología (INC), Bogotá, Colombia.
Materials and methods:
An analytical observational study of a historical cohort was carried out, including patients diagnosed with STS and managed surgically in the Functional Unit for Breast and Soft Tissue Tumors of the INC from January 2008 to December 2018.
Results:
A total of 227 patients were included; 74.5% had tumors greater than 5 cm. Most patients (29.1%) were in stage IIIB at diagnosis. Age was associated with higher mortality (HR=1.01; CI95%: 1–1.02; p=0.048); tumor persistence at admission to the INC (HR=2.34; CI95%: 1.25–4.35; p=0.007), and histologic grade III (HR=5.36; CI95%: 2.29–12.56; p=<0.001) showed statistical significance in the multivariate analysis for recurrence of any type, as were the PFs associated with a higher risk of local recurrence (HR=2.85; CI95%: 1.23–6.57; p=0.014 and HR=6.09; CI95%: 2.03–18.2; p=0.001), respectively. Tumor size (HR=1.03; CI95%: 1–1.06; p=0.015) and histologic grade III (HR=4.53; CI95%: 1.42–14.49; p=0.011) were associated with a higher risk of distant recurrence.
Conclusion:
This cohort showed that in addition to histologic grade and tumor size, tumor persistence at the time of admission has an impact on disease recurrence, so STS should be managed by a multidisciplinary team with experience in this pathology in high-volume reference centers.
Keywords
sarcoma, soft tissues, extremities, treatment.
Subject
Medicine and Pharmacology, Surgery
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
