Wang, Y.; Fang, Y.; Habenicht, A.; Golledge, J.; Giovannucci, E.; Ceriello, A. Postprandial Plasma Glucose and Associated Cancer Mortality. Preprints2024, 2024011578. https://doi.org/10.20944/preprints202401.1578.v1
APA Style
Wang, Y., Fang, Y., Habenicht, A., Golledge, J., Giovannucci, E., & Ceriello, A. (2024). Postprandial Plasma Glucose and Associated Cancer Mortality. Preprints. https://doi.org/10.20944/preprints202401.1578.v1
Chicago/Turabian Style
Wang, Y., Edward Giovannucci and Antonio Ceriello. 2024 "Postprandial Plasma Glucose and Associated Cancer Mortality" Preprints. https://doi.org/10.20944/preprints202401.1578.v1
Abstract
BACKGROUND This study investigated the association of postprandial plasma glucose (PPG) with cancer mortality using a general cohort of US adults. METHODS This cohort study included 14,860 US adults who attended the third National Health and Nutrition Examination Survey from 1988 to 1994, with mortality being followed up to December 31, 2019. The experimental exposures were levels of plasma glucose, including PPG with a fasting time of 0-3.9 h (PPG0-3.9h) and 4-7.9 h (PPG4-7.9h), plasma glucose with a fasting time ≥ 8 h (PGfasting), and plasma glucose at 2 h after oral glucose tolerance test (PG2hOGTT). Plasma glucose-associated cancer mortality risk was assessed using Cox proportional hazards models. RESULTS A 1-natural-log-unit increase in PPG4-7.9h was associated with a higher multivariate-adjusted risk for cancer mortality [hazard ratio (HR), 3.24; 95% confidence interval (CI), 1.50-7.00]. However, PPG0-3.9h, PGfasting, PG2hOGTT, hemoglobin A1c, and insulin were not significantly associated with cancer mortality. The positive association of PPG4-7.9h with cancer mortality remained in those without a prior diagnosis of cancer. CONCLUSIONS High PPG4-7.9h is associated with a higher cancer mortality risk in US adults. Lowering PPG4-7.9h may reduce cancer mortality.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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