Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Carcinogenic Chemicals in Occupational Settings: A Tool for Comparison and Translation between Different Classification Systems

Carolina Zellino
* ,
Andrea Spinazzè
ORCID logo ,
Francesca Borghi
ORCID logo ,
Davide Campagnolo
ORCID logo ,
Giacomo Fanti
ORCID logo ,
Marta Keller
,
Alessio Carminati
ORCID logo ,
Sabrina Rovelli
ORCID logo ,
Andrea Cattaneo
ORCID logo ,
Domenico Maria Cavallo
Version 1 : Received: 19 January 2024 / Approved: 22 January 2024 / Online: 22 January 2024 (10:35:49 CET)

A peer-reviewed article of this Preprint also exists.

Zellino, C.; Spinazzè, A.; Borghi, F.; Campagnolo, D.; Fanti, G.; Keller, M.; Carminati, A.; Rovelli, S.; Cattaneo, A.; Cavallo, D.M. Carcinogenic Chemicals in Occupational Settings: A Tool for Comparison and Translation between Different Classification Systems. Hygiene 2024, 4, 103-114. Zellino, C.; Spinazzè, A.; Borghi, F.; Campagnolo, D.; Fanti, G.; Keller, M.; Carminati, A.; Rovelli, S.; Cattaneo, A.; Cavallo, D.M. Carcinogenic Chemicals in Occupational Settings: A Tool for Comparison and Translation between Different Classification Systems. Hygiene 2024, 4, 103-114.

Abstract

In the European Union, Occupational Safety and Health legislation generally refers to European Regulation (CE) n. 1272/2008 to define and classify carcinogens of concern for occupational risk assessment and exposure assessment. In Europe, the current reference is Directive (UE) 2022/431, regarding carcinogen, mutagen and reprotoxic agents (CMRs) exposure. However, at worldwide level, different classification approaches are used to establish carcinogenicity of substances and it is often difficult to compare the classifications of carcinogenicity (CoCs) proposed by different international bodies. This study aims to investigate a list of carcinogens of concern in occupational settings based on the CLP (Classification Labelling Packaging) CoC, and to create a tool that allows a rapid translation-comparison of some international CoCs with the reference one. CoCs proposed by various sources were consulted and used to apply a translation method, to favor an alignment of different CoCs according to a reference. Results outlined that considering diverse sources, CoCs can result in different classifications of the same chemicals. Overall, this may have implications for the hazard assessment process, which is the base of risk assessment. The proposed tool is expected to help risk assessors in the occupational field when it is needed to have a comparison with different CoC systems.

Keywords

chemical risk assessment; carcinogens; CMR; occupational exposure; classifications of carcinogenicity

Subject

Public Health and Healthcare, Public, Environmental and Occupational Health

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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