Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Usage Patterns of Traditional Chinese Medicine for Patients With Bipolar Disorder: A Population-Based Study in Taiwan

Version 1 : Received: 15 January 2024 / Approved: 15 January 2024 / Online: 15 January 2024 (08:33:16 CET)

A peer-reviewed article of this Preprint also exists.

Chen, S.-P.; Yang, S.-T.; Hu, K.-C.; Satyanarayanan, S.K.; Su, K.-P. Usage Patterns of Traditional Chinese Medicine for Patients with Bipolar Disorder: A Population-Based Study in Taiwan. Healthcare 2024, 12, 490. Chen, S.-P.; Yang, S.-T.; Hu, K.-C.; Satyanarayanan, S.K.; Su, K.-P. Usage Patterns of Traditional Chinese Medicine for Patients with Bipolar Disorder: A Population-Based Study in Taiwan. Healthcare 2024, 12, 490.

Abstract

Background: Patients with bipolar disorder (BD) receive traditional Chinese Medicine (TCM) for unmet clinical needs with psychotropic medications. However, the clinical characteristics of practices and outcomes of TCM in BD are not fully understood. This cohort study investigated the clinical characteristics, principal diagnoses, TCM interventions, and TCM prescriptions in patients with BD. Methods: 12,113 patients with BD were withdrawn from Taiwan's longitudinal health insurance database 2000 (LHID 2000) between 1996 and 2013. Chi-squared test for categorical variables and independent t-test for continuous variables. A p-value less than 0.05 indicated significance. Results: One-thousand and three hundred nineteen patients who visited TCM clinics after the diagnosis of BD were in the TCM group, while those who never visited TCM were in the non-TCM group (N= 1,053). Compared to the non-TCM group, patients in the TCM group had younger average age, a higher percentage of female individuals, more comorbidities of anxiety and alcohol use disorders, and higher mood stabilizer usage rates. The TCM group exhibited pain-related indications, including joint pain, myalgia, myositis, headache, and sleep disturbances. Corydalis yanhusuo and Shu-Jing-Huo-Xue-Tang were the most useful single herb and herbal formulas. Conclusions: Physicians need to be aware of the use of TCM in Patients with BD.

Keywords

Bipolar disorder; herbal medicine; traditional Chinese medicine; Taiwan's National Health Insurance Research Database

Subject

Public Health and Healthcare, Public Health and Health Services

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