Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

The Feasibility of Semi-continuous and Multifrequency Thoracic Bioimpedance Measurements by a Wearable Device during Fluid Changes in Hemodialysis Patients

Melanie Kristien Schoutteten
* ORCID logo ,
Lucas Lindeboom
,
Hélène De Cannière
ORCID logo ,
Zoë Pieters
ORCID logo ,
Liesbeth Bruckers
ORCID logo ,
Astrid Brys
,
Patrick Van der Heijden
,
Bart De Moor
,
Jacques Peeters
,
Chris Van Hoof
,
Willemijn Groenendaal
,
Jeroen P Kooman
,
Pieter M Vandervoort
Version 1 : Received: 9 January 2024 / Approved: 10 January 2024 / Online: 10 January 2024 (06:34:20 CET)

A peer-reviewed article of this Preprint also exists.

Schoutteten, M.K.; Lindeboom, L.; De Cannière, H.; Pieters, Z.; Bruckers, L.; Brys, A.D.H.; van der Heijden, P.; De Moor, B.; Peeters, J.; Van Hoof, C.; Groenendaal, W.; Kooman, J.P.; Vandervoort, P.M. The Feasibility of Semi-Continuous and Multi-Frequency Thoracic Bioimpedance Measurements by a Wearable Device during Fluid Changes in Hemodialysis Patients. Sensors 2024, 24, 1890. Schoutteten, M.K.; Lindeboom, L.; De Cannière, H.; Pieters, Z.; Bruckers, L.; Brys, A.D.H.; van der Heijden, P.; De Moor, B.; Peeters, J.; Van Hoof, C.; Groenendaal, W.; Kooman, J.P.; Vandervoort, P.M. The Feasibility of Semi-Continuous and Multi-Frequency Thoracic Bioimpedance Measurements by a Wearable Device during Fluid Changes in Hemodialysis Patients. Sensors 2024, 24, 1890.

Abstract

Repeated single-point measurements of thoracic bioimpedance at single (low)-frequency are strongly related to fluid changes during hemodialysis. Extension to semi-continuous measurements may provide longitudinal details in the time pattern of the bioimpedance signal, and multifrequency measurements may add in-depth information on the distribution between intra- and extracellular fluid. This study aims to investigate the feasibility of semi-continuous multifrequency thoracic bioimpedance measurements by a wearable device in hemodialysis patients. Therefore, thoracic bioimpedance was recorded semi-continuously (i.e. every ten minutes) at nine frequencies (8 – 160 kHz) in 68 patients during two consecutive hemodialysis sessions, complemented by a single-point measurement at home in-between both sessions. On average, the resistance signals increased during both hemodialysis sessions and decreased during the interdialytic interval. The increase during dialysis was larger at 8 kHz (∆ 32.6 Ω during session 1 and ∆ 10 Ω during session 2) compared to 160 kHz (∆ 29.5 Ω during session 1 and ∆ 5.1 Ω during session 2). Whereas the resistance at 8 kHz showed a linear time pattern, the evolution of the resistance at 160 kHz was significantly different [p < 0.0001]. Measuring bioimpedance semi-continuously and with a multifrequency current is a major step forward in the understanding of fluid dynamics in hemodialysis patients. This study paves the road towards remote fluid monitoring.

Keywords

bioimpedance; thoracic; semi-continuous; multifrequency; wearable

Subject

Medicine and Pharmacology, Other

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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