Santos, I.P.; Silva, L.P.; Silva, D.K.C.; dos Reis, B.P.Z.C.; Oliveira, T.B.; Kelly, A.M.; Rodrigues, E.S.; Souza, C.V.C.; Oliveira-Costa, J.F.; Valverde, S.S.; Santos-Filho, O.A.; Soares, M.B.P.; Meira, C.S. Solidagenone from Solidago chilensis Meyen Protects against Acute Peritonitis and Lipopolysaccharide-Induced Shock by Regulating NF-κB Signaling Pathway. Pharmaceuticals2024, 17, 273.
Santos, I.P.; Silva, L.P.; Silva, D.K.C.; dos Reis, B.P.Z.C.; Oliveira, T.B.; Kelly, A.M.; Rodrigues, E.S.; Souza, C.V.C.; Oliveira-Costa, J.F.; Valverde, S.S.; Santos-Filho, O.A.; Soares, M.B.P.; Meira, C.S. Solidagenone from Solidago chilensis Meyen Protects against Acute Peritonitis and Lipopolysaccharide-Induced Shock by Regulating NF-κB Signaling Pathway. Pharmaceuticals 2024, 17, 273.
Santos, I.P.; Silva, L.P.; Silva, D.K.C.; dos Reis, B.P.Z.C.; Oliveira, T.B.; Kelly, A.M.; Rodrigues, E.S.; Souza, C.V.C.; Oliveira-Costa, J.F.; Valverde, S.S.; Santos-Filho, O.A.; Soares, M.B.P.; Meira, C.S. Solidagenone from Solidago chilensis Meyen Protects against Acute Peritonitis and Lipopolysaccharide-Induced Shock by Regulating NF-κB Signaling Pathway. Pharmaceuticals2024, 17, 273.
Santos, I.P.; Silva, L.P.; Silva, D.K.C.; dos Reis, B.P.Z.C.; Oliveira, T.B.; Kelly, A.M.; Rodrigues, E.S.; Souza, C.V.C.; Oliveira-Costa, J.F.; Valverde, S.S.; Santos-Filho, O.A.; Soares, M.B.P.; Meira, C.S. Solidagenone from Solidago chilensis Meyen Protects against Acute Peritonitis and Lipopolysaccharide-Induced Shock by Regulating NF-κB Signaling Pathway. Pharmaceuticals 2024, 17, 273.
Abstract
Anti-inflammatory agents are widely used for the treatment of inflammatory diseases. Nevertheless, the associated side effects of available drugs make necessary the search for new anti-inflammatory conditions. Here, we investigated the anti-inflammatory activity of solidagenone. Initially, we observed that a single dose of 30, 60 or 90 mg/Kg of solidagenone did not result in mortality or elicit any discernible signs of toxicity in the animals. At the same doses, solidagenone promoted a significative reduction in the migration of neutrophils in an acute peritonitis model and decreased mortality in a lipopolysaccharide-induced endotoxic shock model. Interestingly, treatment with solidagenone conferred a protective effect against leukopenia and thrombocytopenia, hematological disorders commonly observed in sepsis conditions. In addition, treatment with all the doses of solidagenone promoted a significative reduction in nitric oxide, TNF-α, and IL-1β relative to the LPS-stimulated vehicle-treated cultures. Furthermore, gene expression and in silico analyses also supported the modulation of NF-κB pathway by solidagenone. Finally, in silico pharmacokinetics prediction indicated a favorable drugability profile for solidagenone. Taken together, the findings of the present investigation show that solidagenone exhibits significant anti-inflammatory properties in acute experimental models, potentially through the modulation of NF-κB signaling pathway.
Biology and Life Sciences, Immunology and Microbiology
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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