Mascarenhas, C.; Sousa, A.C.A.; Rato, L. Effects of Pharmaceutical Substances with Obesogenic Activity on Male Reproductive Health. Int. J. Mol. Sci.2024, 25, 2324.
Mascarenhas, C.; Sousa, A.C.A.; Rato, L. Effects of Pharmaceutical Substances with Obesogenic Activity on Male Reproductive Health. Int. J. Mol. Sci. 2024, 25, 2324.
Mascarenhas, C.; Sousa, A.C.A.; Rato, L. Effects of Pharmaceutical Substances with Obesogenic Activity on Male Reproductive Health. Int. J. Mol. Sci.2024, 25, 2324.
Mascarenhas, C.; Sousa, A.C.A.; Rato, L. Effects of Pharmaceutical Substances with Obesogenic Activity on Male Reproductive Health. Int. J. Mol. Sci. 2024, 25, 2324.
Abstract
Obesogens have been identified as a significant factor associated with increasing obesity rates, particularly in developed countries. These substances with obesogenic traits are prevalent in consumer products, including certain pharmaceuticals. Specific classes of pharmaceuticals have been recognized for their ability to induce weight gain, often accompanied by hormonal alterations that can adversely impact male fertility. Indeed, research has supplied evidence underscoring the crucial role of obesogens and therapeutic agents in the normal functioning of the male reproductive system. Notably, sperm count, and various semen parameters have been closely linked to a range of environmental and nutritional factors, including chemicals and pharmacological agents exhibiting obesogenic properties. This review aims to explore studies focused on analyzing male fertility parameters, delving into the intricacies of sperm quality, and elucidating the direct and adverse effects that pharmacological agents may have on these aspects.
Keywords
Antidiabetics; Antihypertensives; Endocrine Disruptors; Male Fertility; Obesogens, Psychotropics
Subject
Medicine and Pharmacology, Pharmacology and Toxicology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
