Ranasinghe, A.D.C.U.; Tennakoon, T.M.P.B.; Schwarz, M.A. Emerging Epigenetic Targets and Their Molecular Impact on Vascular Remodeling in Pulmonary Hypertension. Cells2024, 13, 244.
Ranasinghe, A.D.C.U.; Tennakoon, T.M.P.B.; Schwarz, M.A. Emerging Epigenetic Targets and Their Molecular Impact on Vascular Remodeling in Pulmonary Hypertension. Cells 2024, 13, 244.
Ranasinghe, A.D.C.U.; Tennakoon, T.M.P.B.; Schwarz, M.A. Emerging Epigenetic Targets and Their Molecular Impact on Vascular Remodeling in Pulmonary Hypertension. Cells2024, 13, 244.
Ranasinghe, A.D.C.U.; Tennakoon, T.M.P.B.; Schwarz, M.A. Emerging Epigenetic Targets and Their Molecular Impact on Vascular Remodeling in Pulmonary Hypertension. Cells 2024, 13, 244.
Abstract
Pulmonary Hypertension (PH) is a terminal disease characterized by severe pulmonary vascular remodeling. Unfortunately, targeted therapy to prevent disease progression is limited. Here, the vascular cell populations that contribute to the molecular and morphological changes of PH in conjunction with current animal models for studying vascular remodeling in PH will be examined. The status quo of epigenetic targeting for treating vascular remodeling in different PH subtypes will be dissected, while parallel epigenetic threads between pulmonary hypertension and pathogenic cancer provide insight into future therapeutic PH opportunities.
Keywords
vascular remodeling; Pulmonary Hypertension; epigenetic; lung cancer
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
