Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Role of Rosavin in the Pathophysiology of Bone Metabolism

Piotr Wojdasiewicz
* ORCID logo ,
Paweł Turczyn
,
Anna Lach-Gruba
,
Łukasz A. Poniatowski
,
Daryush Purrahman
ORCID logo ,
Mohammad-Reza Mahmoudian-Sani
,
Dariusz Szukiewicz
*
Version 1 : Received: 2 January 2024 / Approved: 4 January 2024 / Online: 4 January 2024 (07:22:17 CET)

A peer-reviewed article of this Preprint also exists.

Wojdasiewicz, P.; Turczyn, P.; Lach-Gruba, A.; Poniatowski, Ł.A.; Purrahman, D.; Mahmoudian-Sani, M.-R.; Szukiewicz, D. The Role of Rosavin in the Pathophysiology of Bone Metabolism. Int. J. Mol. Sci. 2024, 25, 2117. Wojdasiewicz, P.; Turczyn, P.; Lach-Gruba, A.; Poniatowski, Ł.A.; Purrahman, D.; Mahmoudian-Sani, M.-R.; Szukiewicz, D. The Role of Rosavin in the Pathophysiology of Bone Metabolism. Int. J. Mol. Sci. 2024, 25, 2117.

Abstract

Rosavin, a phenylpropanoid in Rhodiola rosea's rhizome, an adaptogen, is known for enhancing the body's response to environmental stress. It significantly affects cellular metabolism in health and many diseases, particularly influencing bone tissue metabolism. In vitro, rosavin inhibits osteoclastogenesis, disrupts F-actin rings formation, and lowers osteoclastogenesis-related gene expression (cathepsin K, CTR, TRAF6, TRAP, MMP-9). It also impedes NFATc1, c-Fos, NF-κB, and MAPK signaling pathways, and blocks phosphorylation processes crucial for bone resorption. Moreover, rosavin promotes osteogenesis, osteoblast differentiation and increases Runx2 and OCN expression. In vivo studies show its effectiveness in enhancing BMD in PMOP mice, re-straining osteoclast maturation, and increasing active osteoblast percentage in bone tissue. It modulates mRNA expressions (increasing EEF2 and decreasing HDAC1, thereby activating os-teoprotective epigenetic mechanisms) and alters various serum markers, including decrease of CTX-1, TRAcp5b, RANKL, M-CSF, TRAP, and increase of ALP and OCN. Additionally, when combined with zinc and probiotics, it reduces pro-osteoporotic MMP-3, IL-6, TNF-α, and en-hances anti-osteoporotic IL-10 and TIMP3 expressions. This paper aims to systematically review rosavin's impact on bone tissue metabolism, exploring its potential in osteoporosis prevention and treatment, and suggesting future research directions.

Keywords

Keywords: rosavin; adaptogens; bone metabolism; osteoblasts; osteoporosis; Rhodiola rosea; bone loss; osteoclastogenesis; osteogenesis

Subject

Medicine and Pharmacology, Dietetics and Nutrition

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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