NLRP3 Inflammasome Activation by Oxidative Stress and Its Implications for Vaccination-Related Adverse Events

Todd Terhune; Taravat Ghafourian; Richard Deth

doi:10.20944/preprints202401.0192.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 2 January 2024 / Approved: 3 January 2024 / Online: 3 January 2024 (08:03:38 CET)

The cytokine-producing nucleotide-binding domain leucine-rich repeat and pyrin-containing receptor 3 (NLRP3) inflammasome is generally recognized to play a central role in the immune response to vaccination and NLRP3 activity is known to be increased by both aluminum adjuvants and by oxidative stress. Thus, the presence of oxidative stress may place individuals at higher risk for exaggerated or prolonged inflammatory responses and related side effects from vaccination. We here examine the relationship between oxidative stress and NLRP3 inflammasome activity, particularly in the context of aluminum-adjuvanted vaccines, and its implications for subpopulations of individuals with restricted antioxidant capacity.

aluminum; asthma; atopy; autism; COVD-19; cysteine; glutathione; IL-1 beta; IL-18; inflammasome; NLRP3; neuroinflammation; Nrf-2; oxidative stress; P2X7

Medicine and Pharmacology, Immunology and Allergy

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NLRP3 Inflammasome Activation by Oxidative Stress and Its Implications for Vaccination-Related Adverse Events

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