PreprintReviewVersion 1Preserved in Portico This version is not peer-reviewed
Fertility Preservation and Ovarian Hyperstimulation Syndrome Management in Cancer Care: A Pathophysiological Perspective on Gonadotropin-Releasing Hormone Agonists and Antagonists – a Narrative Review
Version 1
: Received: 2 January 2024 / Approved: 3 January 2024 / Online: 3 January 2024 (07:50:49 CET)
How to cite:
Bedoschi, G.; Ingold, C.; Navarro, P.A. Fertility Preservation and Ovarian Hyperstimulation Syndrome Management in Cancer Care: A Pathophysiological Perspective on Gonadotropin-Releasing Hormone Agonists and Antagonists – a Narrative Review. Preprints2024, 2024010156. https://doi.org/10.20944/preprints202401.0156.v1
Bedoschi, G.; Ingold, C.; Navarro, P.A. Fertility Preservation and Ovarian Hyperstimulation Syndrome Management in Cancer Care: A Pathophysiological Perspective on Gonadotropin-Releasing Hormone Agonists and Antagonists – a Narrative Review. Preprints 2024, 2024010156. https://doi.org/10.20944/preprints202401.0156.v1
Bedoschi, G.; Ingold, C.; Navarro, P.A. Fertility Preservation and Ovarian Hyperstimulation Syndrome Management in Cancer Care: A Pathophysiological Perspective on Gonadotropin-Releasing Hormone Agonists and Antagonists – a Narrative Review. Preprints2024, 2024010156. https://doi.org/10.20944/preprints202401.0156.v1
APA Style
Bedoschi, G., Ingold, C., & Navarro, P.A. (2024). Fertility Preservation and Ovarian Hyperstimulation Syndrome Management in Cancer Care: A Pathophysiological Perspective on Gonadotropin-Releasing Hormone Agonists and Antagonists – a Narrative Review. Preprints. https://doi.org/10.20944/preprints202401.0156.v1
Chicago/Turabian Style
Bedoschi, G., Caroline Ingold and Paula Andrea Navarro. 2024 "Fertility Preservation and Ovarian Hyperstimulation Syndrome Management in Cancer Care: A Pathophysiological Perspective on Gonadotropin-Releasing Hormone Agonists and Antagonists – a Narrative Review" Preprints. https://doi.org/10.20944/preprints202401.0156.v1
Abstract
This narrative review delves into the evolving landscape of fertility preservation techniques with a particular focus on their use in patients undergoing oncology treatment that carries a risk of ovarian insufficiency. Advances in established methods such as cryopreservation of oocytes and embryos are highlighted and the increasing use of gonadotropin-releasing hormone (GnRH) agonists is discussed. The review also addresses the complexities and controversies associated with these approaches, such as the 'flare-up' effect associated with GnRH agonists and the potential of GnRH antagonists to reduce the risk of ovarian hyperstimulation syndrome. Despite advances in fertility preservation, the report highlights the challenges we face, including the need for personalized treatment protocols and management of associated risks. It calls for continued research and collaboration between healthcare professionals to refine these techniques and ultimately improve reproductive outcomes for patients facing the prospect of fertility-impairing treatment.
Keywords
fertility preservation; ovarian hyperstimulation syndrome; gonadotropin-releasing hormone; quality of life; neoplasms; cryopreservation; drug therapy
Subject
Medicine and Pharmacology, Reproductive Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
