Doxcycline post-exposure prophylaxis: are we using the correct method to assess for effect on antimicrobial resistance?

Thibaut Vanbaelen; Zina Gestels; Said Abdellati; Irith De Baetselier; Sheeba Manoharan-Basil; Chris Kenyon

doi:10.20944/preprints202401.0148.v1

How to cite: Vanbaelen, T.; Gestels, Z.; Abdellati, S.; De Baetselier, I.; Manoharan-Basil, S.; Kenyon, C. Doxcycline post-exposure prophylaxis: are we using the correct method to assess for effect on antimicrobial resistance?. Preprints 2024, 2024010148. https://doi.org/10.20944/preprints202401.0148.v1 Vanbaelen, T.; Gestels, Z.; Abdellati, S.; De Baetselier, I.; Manoharan-Basil, S.; Kenyon, C. Doxcycline post-exposure prophylaxis: are we using the correct method to assess for effect on antimicrobial resistance?. Preprints 2024, 2024010148. https://doi.org/10.20944/preprints202401.0148.v1

Abstract

Most recent studies of doxycycline PEP have assessed doxycycline's effect on antimicrobial resistance by measuring the proportion of colonies of the target species with AMR as the outcome measure. In this study, we show that this method is insufficiently sensitive to detect shifts in MIC distribution.

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Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Doxcycline post-exposure prophylaxis: are we using the correct method to assess for effect on antimicrobial resistance?

Abstract

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Subject

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