Review
Version 1
Preserved in Portico This version is not peer-reviewed
Epigenetic Regulation of EMP/EMT-Dependent Fibrosis
Version 1
: Received: 31 December 2023 / Approved: 2 January 2024 / Online: 3 January 2024 (02:20:30 CET)
A peer-reviewed article of this Preprint also exists.
Sisto, M.; Lisi, S. Epigenetic Regulation of EMP/EMT-Dependent Fibrosis. Int. J. Mol. Sci. 2024, 25, 2775. Sisto, M.; Lisi, S. Epigenetic Regulation of EMP/EMT-Dependent Fibrosis. Int. J. Mol. Sci. 2024, 25, 2775.
Abstract
Fibrosis represents a process characterized by excessive deposition of extracellular matrix (ECM) proteins. It often represents the evolution of pathological conditions, causes organ failure, and can, in extreme cases, compromises the functionality of the organs to the point of causing death. In recent years, considerable efforts have been made to understand the molecular mechanisms underlying fibrotic evolution and to identify possible therapeutic strategies. Great interest has been aroused by the discovery of a molecular association between epithelial to mesenchymal plasticity (EMP), in particular epithelial to mesenchymal transition (EMT), and fibrogenesis, which has led to the identification of complex molecular mechanisms closely interconnected with each other, which could explain EMT-dependent fibrosis. However, the result remains unsatisfactory from a therapeutic point of view. In recent years, advances in epigenetics, which is based on chromatin remodeling through various histone modifications or through the intervention of non-coding RNAs (ncRNAs), have provided more information on the fibrotic process, and this could represent a promising path forward for the identification of innovative therapeutic strategies for organ fibrosis. In this review, we summarize current research on epigenetic mechanisms involved in organ fibrosis, with a focus on epigenetic regulation of EMP/EMT-dependent fibrosis.
Keywords
epigenetic; inflammation; fibrosis; DNA methylation; histone modification; ncRNA
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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