Espinosa, M.E.; Sánchez, R.; Otzen, T.; Bautista-Valarezo, E.; Aguiar, S.; Corrales-Gutierrez, I.; Leon-Larios, F.; Manterola, C. Phenotypic Characterization of Patients with Polycystic Ovary Syndrome in a Population from the Ecuadorian Andes: A Cross-Sectional Study. Journal of Clinical Medicine 2024, 13, 2376, doi:10.3390/jcm13082376.
Espinosa, M.E.; Sánchez, R.; Otzen, T.; Bautista-Valarezo, E.; Aguiar, S.; Corrales-Gutierrez, I.; Leon-Larios, F.; Manterola, C. Phenotypic Characterization of Patients with Polycystic Ovary Syndrome in a Population from the Ecuadorian Andes: A Cross-Sectional Study. Journal of Clinical Medicine 2024, 13, 2376, doi:10.3390/jcm13082376.
Espinosa, M.E.; Sánchez, R.; Otzen, T.; Bautista-Valarezo, E.; Aguiar, S.; Corrales-Gutierrez, I.; Leon-Larios, F.; Manterola, C. Phenotypic Characterization of Patients with Polycystic Ovary Syndrome in a Population from the Ecuadorian Andes: A Cross-Sectional Study. Journal of Clinical Medicine 2024, 13, 2376, doi:10.3390/jcm13082376.
Espinosa, M.E.; Sánchez, R.; Otzen, T.; Bautista-Valarezo, E.; Aguiar, S.; Corrales-Gutierrez, I.; Leon-Larios, F.; Manterola, C. Phenotypic Characterization of Patients with Polycystic Ovary Syndrome in a Population from the Ecuadorian Andes: A Cross-Sectional Study. Journal of Clinical Medicine 2024, 13, 2376, doi:10.3390/jcm13082376.
Abstract
Polycystic Ovary Syndrome (PCOS) is a highly prevalent endocrine-metabolic disorder in women of reproductive age. Diagnosis of this syndrome relies on criteria established by the Rotterdam Consensus, with PCOS phenotypes being crucial for distinguishing potential complications, treatment approaches, and timing. The aim of this study is to characterize the biodemographic, clinical, metabolic, and reproductive variables and their association with PCOS phenotypes in a population from the Ecuadorian Andes. Methodology: A cross-sectional study was conducted with a non-random consecutive sample of 92 women attending the gynecology and endocrinology outpatient clinic at the Technical University of Loja Hospital (UTPL)-Santa Inés, Loja, Ecuador, between January 2022 and July 2023.Results: The average age was 22±3.4 years, predominantly mestizo, urban, single, with higher education and a medium-high socioeconomic status. Oligo-amenorrhea and acne appear strongly associated with phenotypes A and B, while hirsutism and polycystic ovaries on ultrasound show a weaker association with these phenotypes. Alopecia is more prevalent in phenotypes C and D. Triglyceride levels and BMI have a strong association with phenotypes A and B. Total testosterone levels, 17 OH progesterone, LH, and free androgen index show a moderate association with phenotypes A and B, while other reproductive variables exhibit weak associations. Conclusions: Classical phenotypes A and B of PCOS are most common in Andean Ecuadorian women, carrying higher risks of insulin resistance, anovulation, metabolic disorders, and elevated triglycerides compared to phenotypes C and D. Ethnic diversity and sociocultural habits influence the prevalence and clinical manifestations of phenotypes.
Medicine and Pharmacology, Obstetrics and Gynaecology
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