Version 1
: Received: 27 December 2023 / Approved: 28 December 2023 / Online: 28 December 2023 (15:02:19 CET)
How to cite:
Maruntelu, I.; Constantinescu, A.; Covache-Busuioc, R.; Constantinescu, I. The Golgi Apparatus in the Spotlight: A Key Player in Innate Immunity and Intracellular Signaling Pathways. Preprints2023, 2023122171. https://doi.org/10.20944/preprints202312.2171.v1
Maruntelu, I.; Constantinescu, A.; Covache-Busuioc, R.; Constantinescu, I. The Golgi Apparatus in the Spotlight: A Key Player in Innate Immunity and Intracellular Signaling Pathways. Preprints 2023, 2023122171. https://doi.org/10.20944/preprints202312.2171.v1
Maruntelu, I.; Constantinescu, A.; Covache-Busuioc, R.; Constantinescu, I. The Golgi Apparatus in the Spotlight: A Key Player in Innate Immunity and Intracellular Signaling Pathways. Preprints2023, 2023122171. https://doi.org/10.20944/preprints202312.2171.v1
APA Style
Maruntelu, I., Constantinescu, A., Covache-Busuioc, R., & Constantinescu, I. (2023). The Golgi Apparatus in the Spotlight: A Key Player in Innate Immunity and Intracellular Signaling Pathways. Preprints. https://doi.org/10.20944/preprints202312.2171.v1
Chicago/Turabian Style
Maruntelu, I., Razvan-Adrian Covache-Busuioc and Ileana Constantinescu. 2023 "The Golgi Apparatus in the Spotlight: A Key Player in Innate Immunity and Intracellular Signaling Pathways" Preprints. https://doi.org/10.20944/preprints202312.2171.v1
Abstract
The Golgi apparatus, long known for protein processing and vesicular trafficking, has recently emerged as an essential player in innate immune signaling pathways. This review article discusses our growing understanding of Golgi cells' roles in initiating and activating innate immunity pathways. We elaborate on the relevance of membrane connections between Golgi organelles and other organelles such as endoplasmic reticulum, mitochondria, endosomes, and autophagosomes that facilitate efficient access to innate immune signal transduction and subsequent effector responses. Additionally, we discuss microbial strategies that exploit the Golgi while diminishing its associated innate immune responses. By providing greater illumination of its multiple functions and mechanisms of operation, this article offers invaluable insight into how protein processing impacts innate immunity and vice versa.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
