Secular Increasing Trends in Female Thyroid Cancer Incidence in Taiwan: Does It Coincide with Shifting Fertility Rate Patterns

Jiun-Yan Wu; Yuk-Kae Shyu; Yu-Kwang Lee; Yu-Chiao Wang; Chun-Ju Chiang; San-Lin You; Li-Jen Liao; Wan-Lun Hsu; Yong-Chen Chen

doi:10.20944/preprints202312.2140.v1

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preprints.org > public health and healthcare > public, environmental and occupational health > doi: 10.20944/preprints202312.2140.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Secular Increasing Trends in Female Thyroid Cancer Incidence in Taiwan: Does It Coincide with Shifting Fertility Rate Patterns

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Version 1 : Received: 27 December 2023 / Approved: 28 December 2023 / Online: 28 December 2023 (05:20:13 CET)

How to cite: Wu, J.; Shyu, Y.; Lee, Y.; Wang, Y.; Chiang, C.; You, S.; Liao, L.; Hsu, W.; Chen, Y. Secular Increasing Trends in Female Thyroid Cancer Incidence in Taiwan: Does It Coincide with Shifting Fertility Rate Patterns. Preprints 2023, 2023122140. https://doi.org/10.20944/preprints202312.2140.v1 Wu, J.; Shyu, Y.; Lee, Y.; Wang, Y.; Chiang, C.; You, S.; Liao, L.; Hsu, W.; Chen, Y. Secular Increasing Trends in Female Thyroid Cancer Incidence in Taiwan: Does It Coincide with Shifting Fertility Rate Patterns. Preprints 2023, 2023122140. https://doi.org/10.20944/preprints202312.2140.v1

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MDPI and ACS Style

Wu, J.; Shyu, Y.; Lee, Y.; Wang, Y.; Chiang, C.; You, S.; Liao, L.; Hsu, W.; Chen, Y. Secular Increasing Trends in Female Thyroid Cancer Incidence in Taiwan: Does It Coincide with Shifting Fertility Rate Patterns. Preprints 2023, 2023122140. https://doi.org/10.20944/preprints202312.2140.v1

APA Style

Wu, J., Shyu, Y., Lee, Y., Wang, Y., Chiang, C., You, S., Liao, L., Hsu, W., & Chen, Y. (2023). Secular Increasing Trends in Female Thyroid Cancer Incidence in Taiwan: Does It Coincide with Shifting Fertility Rate Patterns. Preprints. https://doi.org/10.20944/preprints202312.2140.v1

Chicago/Turabian Style

Wu, J., Wan-Lun Hsu and Yong-Chen Chen. 2023 "Secular Increasing Trends in Female Thyroid Cancer Incidence in Taiwan: Does It Coincide with Shifting Fertility Rate Patterns" Preprints. https://doi.org/10.20944/preprints202312.2140.v1

Abstract

Background: Thyroid cancer incidence has increased globally in recent decades, especially in females, although its trends in Taiwan have not been studied extensively. This study aimed to investigate changes in female incidence and possible causes of thyroid cancer in Taiwan. Methods: Using the Taiwan Cancer Registry (TCR) Database, age-standardized incidence rates, age-specific incidence rates and birth cohorts were calculated. Correlation between female thyroid cancer incidence and cohort fertility rates were examined. Results: Thyroid cancer incidence increased in Taiwanese female, with age-adjusted rates per 100,000 people increasing from 7.37 during 1995-1999 to 20.53 during 2015-2019, APCs were 5.9% (95% CI, 5.3-6.5). Age-specific incidence rates increased with age, with peak rates occurring at younger ages. The APCs in the 50-54 age group were the highest (6.8%, 95% CI, 6.1-7.5). Incidence rates also increased with later birth cohorts. We observed a significant negative correlation between thyroid cancer incidence and fertility rates in the same birth cohort. Conclusion: We hypothesize that overdiagnosis may be a main reason for the rapidly increasing thyroid cancer incidence in Taiwanese female. Notably, we observed a strong negative correlation between fertility and thyroid cancer incidence. The associations with fertility will be an important subject for future thyroid cancer research.

Keywords

Thyroid cancer incidence; fertility; overdiagnosis; obesity

Subject

Public Health and Healthcare, Public, Environmental and Occupational Health

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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