Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Cornelian Cherry (Cornus mas L.) Fruit Extract Lowers SREBP-1c and C/EBPα in Liver and Alters Various PPAR-α, PPAR-γ, LXR-α Target Genes in Cholesterol-Rich Diet Rabbit Model

Maciej Danielewski
* ORCID logo ,
Andrzej Rapak
ORCID logo ,
Angelika Kruszyńska
,
Małgorzata Małodobra-Mazur
,
Paweł Oleszkiewicz
,
Stanislaw Dzimira
ORCID logo ,
Alicja Zofia Kucharska
ORCID logo ,
Wojciech Słupski
ORCID logo ,
Agnieszka Matuszewska
,
Beata Nowak
ORCID logo ,
Adam Szeląg
,
Narcyz Piórecki
,
Urszula Zaleska-Dorobisz
,
Tomasz Sozański
Version 1 : Received: 25 December 2023 / Approved: 26 December 2023 / Online: 26 December 2023 (11:27:47 CET)

A peer-reviewed article of this Preprint also exists.

Danielewski, M.; Rapak, A.; Kruszyńska, A.; Małodobra-Mazur, M.; Oleszkiewicz, P.; Dzimira, S.; Kucharska, A.Z.; Słupski, W.; Matuszewska, A.; Nowak, B.; Szeląg, A.; Piórecki, N.; Zaleska-Dorobisz, U.; Sozański, T. Cornelian Cherry (Cornus mas L.) Fruit Extract Lowers SREBP-1c and C/EBPα in Liver and Alters Various PPAR-α, PPAR-γ, LXR-α Target Genes in Cholesterol-Rich Diet Rabbit Model. Int. J. Mol. Sci. 2024, 25, 1199. Danielewski, M.; Rapak, A.; Kruszyńska, A.; Małodobra-Mazur, M.; Oleszkiewicz, P.; Dzimira, S.; Kucharska, A.Z.; Słupski, W.; Matuszewska, A.; Nowak, B.; Szeląg, A.; Piórecki, N.; Zaleska-Dorobisz, U.; Sozański, T. Cornelian Cherry (Cornus mas L.) Fruit Extract Lowers SREBP-1c and C/EBPα in Liver and Alters Various PPAR-α, PPAR-γ, LXR-α Target Genes in Cholesterol-Rich Diet Rabbit Model. Int. J. Mol. Sci. 2024, 25, 1199.

Abstract

Cornelian cherry (Cornus mas L.) fruits, abundant in iridoids and anthocyanins, are natural products with proven beneficial impact on the functions of the cardiovascular system and the liver. The aim of this study is to stipulate and compare whether and to what extent two different doses of resin-purified cornelian cherry extract (10 mg/kg b.w. or 50 mg/kg b.w.) applied in a cholesterol-rich diet rabbit model affect the levels of ATP-binding cassette transporter A1, ATP-binding cassette transporter G1, CCAAT/enhancer binding protein α, sterol regulatory ele-ment-binding protein 1c, fatty acid synthase, endothelial lipase, carnitine palmitoyltransferase 1A, and adiponectin receptor 2 in liver tissue; lipoprotein lipase, visceral adipose tissue-derived serine protease inhibitor, and retinol-binding protein 4 in visceral adipose tissue; resistive index of com-mon carotid arteries and aortas, and histopathological changes in CCAs. Obtained outcomes are referred to the results of our previous works. Moreover, our study, to our knowledge, test the in-fluence of Cornus derivative on CPT1A, AdipoR2, RBP4, LIPG, and vaspin for the first time, with a relevant outcome for the first three. Oral administration of the cornelian cherry extract decreased the SREBP-1c and C/EBPα in both doses. The dose of 10 mg/kg b.w. increased ABCA1 and de-creased FAS, CPT1A, and RBP4, and the dose of 50 mg/kg b.w. enhanced ABCG1 and AdipoR2. Mitigation in atheromatous changes in rabbits’ CCAs was also observed. The beneficial results confirm that cornelian cherry fruit extract may constitute a potentially effective product in the prevention and treatment of obesity-related disorders.

Keywords

cornelian cherry; Cornus mas L.; iridoid; anthocyanin; transcription factor; ATP-binding cassette transporter; adipokine; common carotid artery; atherosclerosis; cardiovascular disease

Subject

Medicine and Pharmacology, Dietetics and Nutrition

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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