The Healthy and Diseased Retina Seen through Neuron-Glia Interactions

Matheus Heidemann Tempone; Vladimir Pedro Borges-Martins; Felipe Godinho Galvão César; Dio Pablo Alexandrino-Mattos; Camila Saggioro De Figueiredo; Icaro Raony; Aline Araujo Dos Santos; Aline Teixeira Duarte-Silva; Mariana Santana Dias; Hercules Rezende Freitas; Elizabeth Giestal De Araújo; Victor Tulio Ribeiro-Resende; Marcelo Cossenza; Hilda Petrs-Silva; Roberto Paes-de-Carvalho; Ana Lucia Marques Ventura; Karin da Costa Calaza; Mariana Souza Silveira; Regina Célia Cussa Kubrusly; Ricardo Augusto De Melo Reis

doi:10.20944/preprints202312.1868.v1

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preprints.org > medicine and pharmacology > neuroscience and neurology > doi: 10.20944/preprints202312.1868.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Healthy and Diseased Retina Seen through Neuron-Glia Interactions

Matheus Heidemann Tempone

Vladimir Pedro Borges-Martins

Felipe Godinho Galvão César

Dio Pablo Alexandrino-Mattos

Camila Saggioro De Figueiredo

Icaro Raony

Aline Araujo Dos Santos

Aline Teixeira Duarte-Silva

Mariana Santana Dias

Hercules Rezende Freitas

Elizabeth Giestal De Araújo

Victor Tulio Ribeiro-Resende

Marcelo Cossenza

Hilda Petrs-Silva

Roberto Paes-de-Carvalho

Ana Lucia Marques Ventura

Karin da Costa Calaza

Mariana Souza Silveira

Regina Célia Cussa Kubrusly

Ricardo Augusto De Melo Reis

Version 1 : Received: 22 December 2023 / Approved: 25 December 2023 / Online: 25 December 2023 (11:12:22 CET)
Version 2 : Received: 4 January 2024 / Approved: 5 January 2024 / Online: 5 January 2024 (12:13:12 CET)

A peer-reviewed article of this Preprint also exists.

Tempone, M.H.; Borges-Martins, V.P.; César, F.; Alexandrino-Mattos, D.P.; de Figueiredo, C.S.; Raony, Í.; dos Santos, A.A.; Duarte-Silva, A.T.; Dias, M.S.; Freitas, H.R.; de Araújo, E.G.; Ribeiro-Resende, V.T.; Cossenza, M.; P. Silva, H.; P. de Carvalho, R.; Ventura, A.L.M.; Calaza, K.C.; Silveira, M.S.; Kubrusly, R.C.C.; de Melo Reis, R.A. The Healthy and Diseased Retina Seen through Neuron–Glia Interactions. Int. J. Mol. Sci. 2024, 25, 1120. Tempone, M.H.; Borges-Martins, V.P.; César, F.; Alexandrino-Mattos, D.P.; de Figueiredo, C.S.; Raony, Í.; dos Santos, A.A.; Duarte-Silva, A.T.; Dias, M.S.; Freitas, H.R.; de Araújo, E.G.; Ribeiro-Resende, V.T.; Cossenza, M.; P. Silva, H.; P. de Carvalho, R.; Ventura, A.L.M.; Calaza, K.C.; Silveira, M.S.; Kubrusly, R.C.C.; de Melo Reis, R.A. The Healthy and Diseased Retina Seen through Neuron–Glia Interactions. Int. J. Mol. Sci. 2024, 25, 1120.

Abstract

The retina is the sensory tissue responsible for the first stages of visual processing, with a conserved anatomy and functional architecture among vertebrates. To date, retinal eye diseases, such as diabetic retinopathy, age-related macular degeneration, retinitis pigmentosa, glaucoma and others, affect nearly 170 million people worldwide, resulting in vision loss and blindness. To tackle retinal disorders, the embryonic retina has been explored as a versatile model to study development, with a broad neurochemical repertoire, approached in the last decades in terms of signaling and diseases. Retina, dissociated and arranged as typical cultures are valuable to understand both neuronal and glial compartments, as mixed or neuron- and glia-enriched, and/or organized as neurospheres and/or as organoids which have contributed to reveal mechanisms between transmitter systems as well as antioxidants, trophic factors, and extracellular matrix proteins. Overall, contributions in understanding neurogenesis, tissue development, differentiation, connectivity, plasticity, and cell death are widely described. A complete access to the genome of several vertebrates, as well the recent transcriptome at the single cell level at different stages of development also anticipates future advances in providing cues to target blinding diseases or retinal dysfunctions.

Keywords

retina; signaling; disease; neuron; glia

Subject

Medicine and Pharmacology, Neuroscience and Neurology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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