Walton, N.I.; Brozek, E.M.; Gwinn, C.C.; Zharov, I. The Synthesis and Reactivity of Mesoporous and Surface-Rough Vinyl-Containing ORMOSIL Nanoparticles. Colloids Interfaces2024, 8, 18.
Walton, N.I.; Brozek, E.M.; Gwinn, C.C.; Zharov, I. The Synthesis and Reactivity of Mesoporous and Surface-Rough Vinyl-Containing ORMOSIL Nanoparticles. Colloids Interfaces 2024, 8, 18.
Walton, N.I.; Brozek, E.M.; Gwinn, C.C.; Zharov, I. The Synthesis and Reactivity of Mesoporous and Surface-Rough Vinyl-Containing ORMOSIL Nanoparticles. Colloids Interfaces2024, 8, 18.
Walton, N.I.; Brozek, E.M.; Gwinn, C.C.; Zharov, I. The Synthesis and Reactivity of Mesoporous and Surface-Rough Vinyl-Containing ORMOSIL Nanoparticles. Colloids Interfaces 2024, 8, 18.
Abstract
Silica nanoparticles synthesized solely from organosilanes naturally possess a greater number of organic functionalities than silica nanoparticles surface modified with organosilanes. We report the synthesis of organically modified silica (ORMOSIL) nanoparticles with mesoporous and surface rough morphology and with high surface area, made solely from vinyltrimethoxy silane. We chemically modified these vinyl silica nanoparticles using bromination and hydroboration, and demonstrated the high accessibility and reactivity of the vinyl groups with an ~85% conversion of the functional groups for bromination of both particle types, a ~60% conversion of the functional groups for hydroboration of surface rough particles and a 90% conversion of the functional groups for hydroboration of mesoporous particles. We determined that the mesoporous vinyl silica nanopar-ticles, while having a surface area that lies between the non-porous and surface rough vinyl silica nanoparticles, provide the greatest accessibility to the vinyl groups for boronation and allow in-corporating up to 3.1 × 106 B atoms per particle, making the resulting materials attractive for boron neutron capture therapy.
Chemistry and Materials Science, Materials Science and Technology
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