PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Comprehensive multi-omics analysis revealed that mulberry leaf dietary supplementation can improve the lipo-nutritional quality of pork and regulate gut microbiota in pigs
Version 1
: Received: 23 December 2023 / Approved: 25 December 2023 / Online: 25 December 2023 (09:29:27 CET)
How to cite:
Hou, J.; Ji, X.; Chu, X.; Wang, B.; Sun, K.; Wei, H.; Zhang, Y.; Song, Z.; Wen, F. Comprehensive multi-omics analysis revealed that mulberry leaf dietary supplementation can improve the lipo-nutritional quality of pork and regulate gut microbiota in pigs. Preprints2023, 2023121798. https://doi.org/10.20944/preprints202312.1798.v1
Hou, J.; Ji, X.; Chu, X.; Wang, B.; Sun, K.; Wei, H.; Zhang, Y.; Song, Z.; Wen, F. Comprehensive multi-omics analysis revealed that mulberry leaf dietary supplementation can improve the lipo-nutritional quality of pork and regulate gut microbiota in pigs. Preprints 2023, 2023121798. https://doi.org/10.20944/preprints202312.1798.v1
Hou, J.; Ji, X.; Chu, X.; Wang, B.; Sun, K.; Wei, H.; Zhang, Y.; Song, Z.; Wen, F. Comprehensive multi-omics analysis revealed that mulberry leaf dietary supplementation can improve the lipo-nutritional quality of pork and regulate gut microbiota in pigs. Preprints2023, 2023121798. https://doi.org/10.20944/preprints202312.1798.v1
APA Style
Hou, J., Ji, X., Chu, X., Wang, B., Sun, K., Wei, H., Zhang, Y., Song, Z., & Wen, F. (2023). Comprehensive multi-omics analysis revealed that mulberry leaf dietary supplementation can improve the lipo-nutritional quality of pork and regulate gut microbiota in pigs. Preprints. https://doi.org/10.20944/preprints202312.1798.v1
Chicago/Turabian Style
Hou, J., Zhen Song and Fengyun Wen. 2023 "Comprehensive multi-omics analysis revealed that mulberry leaf dietary supplementation can improve the lipo-nutritional quality of pork and regulate gut microbiota in pigs" Preprints. https://doi.org/10.20944/preprints202312.1798.v1
Abstract
Results showed that mulberry leaves could significantly reduce backfat thickness (P<0.05) and increase intramuscular fat (IMF) content (P<0.05). Lipidomics analysis showed that mulberry leaves improved lipid profile composition and increased the proportion of triglycerides (TG). Interestingly, IMF content was positively correlated with acyl C18:2 and negatively correlated with C18:1 of differential TGs. In addition, cecal microbiological analysis showed that mulberry leaves could increase the abundance of bacteria such as UCG−005, Muribaculaceae_norank, Prevotellaceae_NK3B31_group, Limosilactobacillus, and so on. At the same time improve the L-tyrosine-baton rouge ester, Oleic acid methyl ester, 21-deoxycortisol, N-acetyldihydrosphingosine, Mulberrin relative abundance. In this study, we found that mulberry leaves could extremely significantly increasing the mRNA relative expression of lipoprotein lipase (LPL), fatty acid-binding protein 4 (FABP4) and peroxisome proliferators-activated receptor γ (PPARγ) in muscle (P＜0.01), significantly increasing mRNA relative expression of diacylglycerol acyltransferase 1 (DGAT1) (P＜0.05) and significantly decreasing the mRNA relative expression of acetyl CoA carboxylase (ACC) (P＜0.05), and aignificantly upregulated hormone-sensitive triglyceride lipase (HSL), peroxisome proliferators-activated receptor α (PPARα) mRNA relative expression (P＜0.05) in backfat. In addition mulberry leaves could increased serum leptin and adiponectin (P＜0.01). Ultimately lead to up-regulation of IMF and down-regulation of backfat.
Biology and Life Sciences, Food Science and Technology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
