Cho, S.B. Comorbidity Genes of Alzheimer’s Disease and Type 2 Diabetes Associated with Memory and Cognitive Function. International Journal of Molecular Sciences 2024, 25, 2211, doi:10.3390/ijms25042211.
Cho, S.B. Comorbidity Genes of Alzheimer’s Disease and Type 2 Diabetes Associated with Memory and Cognitive Function. International Journal of Molecular Sciences 2024, 25, 2211, doi:10.3390/ijms25042211.
Cho, S.B. Comorbidity Genes of Alzheimer’s Disease and Type 2 Diabetes Associated with Memory and Cognitive Function. International Journal of Molecular Sciences 2024, 25, 2211, doi:10.3390/ijms25042211.
Cho, S.B. Comorbidity Genes of Alzheimer’s Disease and Type 2 Diabetes Associated with Memory and Cognitive Function. International Journal of Molecular Sciences 2024, 25, 2211, doi:10.3390/ijms25042211.
Abstract
Alzheimer’s disease (AD) and type 2 diabetes mellitus (T2DM) are comorbidities that result from the sharing of common genes. The molecular background of comorbidities can provide clues for the development of treatment and management strategies. Here, the common genes involved in the development of the two diseases and in memory and cognitive function are reviewed. Network clustering based on protein-protein interaction networks identified tightly connected gene clusters that have an impact on memory and cognition among the comorbidity genes of AD and T2DM. Genes with functional implications were intensively reviewed, and relevant evidence was summarized. Gene information will be useful in the discovery of biomarkers and the identification of therapeutic targets for AD.
Keywords
Alzheimer’s disease; type 2 diabetes; comorbidity; memory; cognition.
Subject
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
