Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

A Comprehensive Review of COVID-19 Infection and Steroid-Associated Treatment Bone Avascular Necrosis: A Multi-Study Analysis

Evangelos Sakellariou
,
Evangelia Argyropoulou
* ORCID logo ,
Panagiotis Karampinas
,
Athanasios Galanis
,
Iordanis Varsamos
,
Vasileios Giannatos
,
Elias Vasiliadis
ORCID logo ,
Angelos Kaspiris
ORCID logo ,
John Vlamis
,
Spiros Pneumaticos
Version 1 : Received: 18 December 2023 / Approved: 19 December 2023 / Online: 19 December 2023 (11:49:45 CET)

A peer-reviewed article of this Preprint also exists.

Sakellariou, E.; Argyropoulou, E.; Karampinas, P.; Galanis, A.; Varsamos, I.; Giannatos, V.; Vasiliadis, E.; Kaspiris, A.; Vlamis, J.; Pneumaticos, S. A Comprehensive Review of COVID-19-Infection- and Steroid-Treatment-Associated Bone Avascular Necrosis: A Multi-Study Analysis. Diagnostics 2024, 14, 247. Sakellariou, E.; Argyropoulou, E.; Karampinas, P.; Galanis, A.; Varsamos, I.; Giannatos, V.; Vasiliadis, E.; Kaspiris, A.; Vlamis, J.; Pneumaticos, S. A Comprehensive Review of COVID-19-Infection- and Steroid-Treatment-Associated Bone Avascular Necrosis: A Multi-Study Analysis. Diagnostics 2024, 14, 247.

Abstract

Background: The COVID-19 pandemic has presented numerous challenges to global healthcare system and emerging evidence suggests a potential link between COVID-19 treatment, specifically steroid therapy, and the development of avascular necrosis (AVN) of the hip. This review aims to provide a comprehensive overview of recent studies and case reports investigating the relationship between COVID-19, corticosteroid therapy, and the development of AVN. Understanding the nuances of AVN in the context of COVID-19 is crucial for healthcare professionals to navigate treatment decisions and mitigate potential complications. Materials and Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) was used in the systematic review until September 1st, 2023. The full-texts of the remaining twenty-three (n=23) articles were independently reviewed by the authors of this review.  Conclusions: The association between steroid therapy for COVID-19 and the development of hip AVN is a noteworthy concern even though, no relationship is evident between the duration of treatment, cumulative dosage of medication, maximum daily dosage received, and the presence of AVN. Further research with larger cohorts and long-term follow-up is needed to better understand the causative relationship and optimal management strategies for hip AVN in the context of COVID-19 and steroid therapy

Keywords

COVID-19; AVN; bone avascular necrosis; osteonecrosis; hip pain; steroids

Subject

Medicine and Pharmacology, Orthopedics and Sports Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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